Granulocyte Colony-stimulating Factor Associated Arteritis in a Patient with Castration-resistant Prostate Cancer

Overview

Journal IJU Case Rep

Date 2022 Jan 10

PMID 35005466

Authors

Satoshi Nitta

Takazo Tanaka

Ryota Yanagihashi

Haruna Nonaka

Shuhei Suzuki

Tomokazu Kimura

Shuya Kandori

Akio Hoshi

Hiromitsu Negoro

Hiroyuki Nishiyama

Affiliations

Soon will be listed here.

Abstract

Introduction: Granulocyte colony-stimulating factor-associated arteritis is a rare adverse event of granulocyte colony-stimulating factor, with an incidence of 0.47% among all patients who receive granulocyte colony-stimulating factor. We herein present a case of granulocyte colony-stimulating factor-associated arteritis.

Case Presentation: A 72-year-old man with castration-resistant prostate cancer and multiple bone metastases was treated with docetaxel and pegfilgrastim. He developed a high fever on day 12 without other symptoms. His white blood cell count and C-reactive protein levels were high. Antibiotic therapy was ineffective, and contrast-enhanced computed tomography showed thickened subclavian and brachiocephalic artery walls. He was diagnosed with granulocyte colony-stimulating factor-associated arteritis.

Conclusion: When patients receiving chemotherapy with granulocyte colony-stimulating factor develop an unexplained fever, granulocyte colony-stimulating factor associated arteritis should be considered.

Citing Articles

Literature review analysis of aortitis induced by granulocyte-colony stimulating factor.

Zhao T, Xu H Front Pharmacol. 2025; 15:1487501.

PMID: 39744136 PMC: 11688214. DOI: 10.3389/fphar.2024.1487501.

Granulocyte colony-stimulating factor associated arteritis in a patient with castration-resistant prostate cancer.

Nitta S, Tanaka T, Yanagihashi R, Nonaka H, Suzuki S, Kimura T IJU Case Rep. 2022; 5(1):29-31.

PMID: 35005466 PMC: 8720713. DOI: 10.1002/iju5.12376.

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