Role of Circular RNAs in Gastrointestinal Tumors and Drug Resistance

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2022 Jan 10

PMID 35004973

Authors

Shi-Jun Xi

Wen-Qi Cai

Qin-Qi Wang

Xiao-Chun Peng

Affiliations

Soon will be listed here.

Abstract

The incidence of gastrointestinal cancers has increased significantly over the past decade and gastrointestinal malignancies now rank among the leading causes of mortality globally. Although newer therapeutic strategies such as targeted therapies have greatly improved patient outcomes, their clinical success is limited by drug resistance, treatment failure and recurrence of metastatic disease. Therefore, there is an urgent need for further research identifying accurate and reliable biomarkers for precise treatment strategies. Circular RNAs (circRNAs) exhibit a covalently closed structure, high stability and biological conservation, and their expression is associated with the occurrence and development of gastrointestinal tumors. Moreover, circRNAs may significantly influence drug resistance of gastrointestinal cancers. In this article, we review the role of circRNAs in the occurrence and development of gastrointestinal cancer, their association with drug resistance, and potential application for early diagnosis, treatment and prognosis in gastrointestinal malignancies. Furthermore, we summarize characteristics of circRNA, including mechanism of formation and biological effects mRNA sponging, chromatin replication, gene regulation, translational modification, signal transduction, and damage repair. Finally, we discuss whether circRNA-related noninvasive testing may be clinically provided in the future. This review provides new insights for the future development of diagnostics and therapeutics based on circRNAs in gastrointestinal tumors.

Citing Articles

Therapeutic and diagnostic applications of exosomes in colorectal cancer.

Shakerian N, Darzi-Eslam E, Afsharnoori F, Bana N, Noorabad Ghahroodi F, Tarin M Med Oncol. 2024; 41(8):203.

PMID: 39031221 DOI: 10.1007/s12032-024-02440-3.

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-κB) pathway.

Zhou Y, Tang W, Zhuo H, Zhu D, Rong D, Sun J Bioengineered. 2022; 13(3):4786-4797.

PMID: 35139763 PMC: 8973934. DOI: 10.1080/21655979.2022.2032972.

References

Li X, Wang J, Zhang C, Lin C, Zhang J, Zhang W . Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. J Pathol. 2018; 246(2):166-179. DOI: 10.1002/path.5125. View

Kumala S, Fujarewicz K, Jayaraju D, Rzeszowska-Wolny J, Hancock R . Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors. PLoS One. 2013; 8(1):e52966. PMC: 3559499. DOI: 10.1371/journal.pone.0052966. View

Zhao Z, Song J, Tang B, Fang S, Zhang D, Zheng L . CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway. J Exp Clin Cancer Res. 2020; 39(1):259. PMC: 7687771. DOI: 10.1186/s13046-020-01769-7. View

Qu S, Zhong Y, Shang R, Zhang X, Song W, Kjems J . The emerging landscape of circular RNA in life processes. RNA Biol. 2016; 14(8):992-999. PMC: 5680710. DOI: 10.1080/15476286.2016.1220473. View

Nakamoto K, Abe N, Tsuji G, Kimura Y, Tomoike F, Shimizu Y . Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling circle translation. Chem Commun (Camb). 2020; 56(46):6217-6220. DOI: 10.1039/d0cc02140g. View

Sun P, Fan X, Hu X, Fu X, Wei Q, Zang Y . circPCNX and Pecanex Promote Hepatocellular Carcinoma Cell Viability by Inhibiting miR-506. Cancer Manag Res. 2020; 11:10957-10967. PMC: 6997225. DOI: 10.2147/CMAR.S232940. View

Jian X, He H, Zhu J, Zhang Q, Zheng Z, Liang X . Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340. Mol Cancer. 2020; 19(1):20. PMC: 6993513. DOI: 10.1186/s12943-020-1134-8. View

Tang L, Xiong W, Zhang L, Wang D, Wang Y, Wu Y . circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma. Oncogene. 2020; 40(2):307-321. DOI: 10.1038/s41388-020-01531-5. View

Abu N, Hon K, Jeyaraman S, Yahaya A, Abdullah N, Mustangin M . Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer. Epigenomics. 2019; 11(8):875-884. DOI: 10.2217/epi-2019-0042. View

10.

Xu X, Zhang J, Tian Y, Gao Y, Dong X, Chen W . CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer. 2020; 19(1):128. PMC: 7446195. DOI: 10.1186/s12943-020-01246-x. View

11.

Ren T, Liu C, Hou J, Shan F . CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis. Eur Rev Med Pharmacol Sci. 2020; 24(4):1743-1754. DOI: 10.26355/eurrev_202002_20351. View

12.

Xu T, Wang M, Jiang L, Ma L, Wan L, Chen Q . CircRNAs in anticancer drug resistance: recent advances and future potential. Mol Cancer. 2020; 19(1):127. PMC: 7429705. DOI: 10.1186/s12943-020-01240-3. View

13.

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T . CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Cell Death Dis. 2018; 9(4):417. PMC: 5856798. DOI: 10.1038/s41419-018-0454-8. View

14.

Zou F, Yang S, Li W, Liu C, Liu X, Hu C . circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer. Int J Oncol. 2020; 57(1):151-160. PMC: 7252462. DOI: 10.3892/ijo.2020.5050. View

15.

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X . Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015; 22(3):256-64. DOI: 10.1038/nsmb.2959. View

16.

Dong R, Ma X, Chen L, Yang L . Increased complexity of circRNA expression during species evolution. RNA Biol. 2016; 14(8):1064-1074. PMC: 5680680. DOI: 10.1080/15476286.2016.1269999. View

17.

Jonaitis P, Kiudelis V, Streleckiene G, Gedgaudas R, Skieceviciene J, Kupcinskas J . Novel Biomarkers in the Diagnosis of Benign and Malignant Gastrointestinal Diseases. Dig Dis. 2021; 40(1):1-13. DOI: 10.1159/000515522. View

18.

Wang X, Zhang H, Yang H, Bai M, Ning T, Deng T . Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer. Mol Oncol. 2020; 14(3):539-555. PMC: 7053238. DOI: 10.1002/1878-0261.12629. View

19.

Varughese L, Lau-Min K, Cambareri C, Damjanov N, Massa R, Reddy N . DPYD and UGT1A1 Pharmacogenetic Testing in Patients with Gastrointestinal Malignancies: An Overview of the Evidence and Considerations for Clinical Implementation. Pharmacotherapy. 2020; 40(11):1108-1129. PMC: 8796462. DOI: 10.1002/phar.2463. View

20.

Wang S, Tang D, Wang W, Yang Y, Wu X, Wang L . circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer. Mol Cancer. 2019; 18(1):162. PMC: 6854648. DOI: 10.1186/s12943-019-1081-4. View