Assessment of the Acute and Sub-acute Toxicity of the Ethanolic Extract of the Aerial Parts of (Asteraceae) in Rats

Overview

Journal Toxicol Rep

Date 2022 Jan 10

PMID 35004182

Authors

Pang-Kuei Hsu

Yueh-Ting Tsai

Yu-Cheng Lin

Chen-Meng Kuan

Affiliations

Soon will be listed here.

Abstract

This pioneering study was to assess the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of (Asteraceae) in rats. is a common vegetable and herb for treating inflammation-related syndromes in Taiwan. Pharmacological studies have unveiled that the extracts of have potential to become hepatoprotective, anti-inflammatory, or anti-cancer agents. The toxicological effects of the aerial parts of in rodents are still elusive. For the acute toxicity study, rats were administrated with a single dose of 5,000 mg/kg body weight (BW) and observed for 14 days in accordance with the Organization for Economic Cooperation and Development (OECD) guideline No. 420. For the sub-acute toxicity study, animals were orally treated with daily doses of 0, 416.7, 833.3, and 1,666.7 mg/kg BW for 28 days based on the OECD guideline No. 407. The toxicity of the repeated dose was observed with anthropometric, hematological, and biochemical parameters as well as histology. The mortality and critical pathological and biochemical abnormalities were not observed in the acute and/or sub-acute toxicity studies. The oral median lethal dose (LD) of the extract was greater than 5000 mg/kg BW. The no-observed-adverse-effect-level (NOAEL) in male and female rats was greater than 1,666.7 mg/kg BW. As such, the extract of the aerial parts of is considered a non-toxic substance.

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