Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 May 24

PMID 31119149

Citations 14

Authors

Yingying Pan

Mingzhu Cao

Danming You

Genggeng Qin

Zhi Liu

Affiliations

Soon will be listed here.

Abstract

Drug-induced liver injury (DILI) is a major concern in clinical studies as well as in postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough investigation of mechanisms of DILI and searching for protective medications. This article reviews the current status and future perspective on establishment of DILI models based on different hepatotoxic drugs, as well as the underlying mechanisms of liver function damage induced by specific medicine. Therefore, information from this article can help researchers make a suitable selection of animal models for further study.

Citing Articles

In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs.

Haller K, Doss S, Sauer M Curr Issues Mol Biol. 2024; 46(4):3022-3038.

PMID: 38666919 PMC: 11049542. DOI: 10.3390/cimb46040189.

Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis.

Zhao S, Feng Y, Zhang J, Zhang Q, Wang J, Cui S BMC Med Genomics. 2024; 17(1):80.

PMID: 38549107 PMC: 10976682. DOI: 10.1186/s12920-024-01848-0.

Eriodictyol Alleviated LPS/D-GalN-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Cell Apoptosis via PI3K/AKT Signaling Pathway.

Zheng X, Wu X, Wen Q, Tang H, Zhao L, Shi F Nutrients. 2023; 15(20).

PMID: 37892424 PMC: 10609606. DOI: 10.3390/nu15204349.

Application of multiple-finding segmentation utilizing Mask R-CNN-based deep learning in a rat model of drug-induced liver injury.

Baek E, Lee J, Hwang J, Park H, Lee B, Kim Y Sci Rep. 2023; 13(1):17555.

PMID: 37845356 PMC: 10579263. DOI: 10.1038/s41598-023-44897-8.

Chemistry-Based Modeling on Phenotype-Based Drug-Induced Liver Injury Annotation: From Public to Proprietary Data.

Moein M, Heinonen M, Mesens N, Chamanza R, Amuzie C, Will Y Chem Res Toxicol. 2023; 36(8):1238-1247.

PMID: 37556769 PMC: 10445287. DOI: 10.1021/acs.chemrestox.2c00378.

References

Aithal G, Rawlins M, Day C . Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions. J Hepatol. 2000; 33(6):949-52. DOI: 10.1016/s0168-8278(00)80127-0. View

Odin J, Huebert R, Casciola-Rosen L, Larusso N, Rosen A . Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest. 2001; 108(2):223-32. PMC: 203018. DOI: 10.1172/JCI10716. View

Su G . Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol. 2002; 283(2):G256-65. DOI: 10.1152/ajpgi.00550.2001. View

Letteron P, Sutton A, Mansouri A, Fromenty B, Pessayre D . Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology. 2003; 38(1):133-40. DOI: 10.1053/jhep.2003.50309. View

Luyendyk J, Maddox J, Cosma G, Ganey P, Cockerell G, Roth R . Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J Pharmacol Exp Ther. 2003; 307(1):9-16. DOI: 10.1124/jpet.103.054288. View

Kostrubsky V, Strom S, Hanson J, Urda E, Rose K, Burliegh J . Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol Sci. 2003; 76(1):220-8. DOI: 10.1093/toxsci/kfg217. View

Roth R, Luyendyk J, Maddox J, Ganey P . Inflammation and drug idiosyncrasy--is there a connection?. J Pharmacol Exp Ther. 2003; 307(1):1-8. DOI: 10.1124/jpet.102.041624. View

James L, Mayeux P, Hinson J . Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003; 31(12):1499-506. DOI: 10.1124/dmd.31.12.1499. View

Hagar H . The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicol Lett. 2004; 151(2):335-43. DOI: 10.1016/j.toxlet.2004.03.002. View

10.

Hewett J, Schultze A, VanCise S, Roth R . Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab Invest. 1992; 66(3):347-61. View

11.

Peng B, Miao M, Wang Y . [Initial discussion of mice acute hepatic injury caused by Tripterygium glycosides]. Zhongguo Zhong Yao Za Zhi. 2004; 28(11):1067-70. View

12.

Tong V, Teng X, Chang T, Abbott F . Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci. 2005; 86(2):427-35. DOI: 10.1093/toxsci/kfi184. View

13.

Kaplowitz N . Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005; 4(6):489-99. DOI: 10.1038/nrd1750. View

14.

Luyendyk J, Shaw P, Green C, Maddox J, Ganey P, Roth R . Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J Pharmacol Exp Ther. 2005; 314(3):1023-31. DOI: 10.1124/jpet.105.087981. View

15.

Bjornsson E, Olsson R . Outcome and prognostic markers in severe drug-induced liver disease. Hepatology. 2005; 42(2):481-9. DOI: 10.1002/hep.20800. View

16.

Warner T, Patsalos P, Prevett M, Elyas A, Duncan J . Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11-epoxide. Epilepsy Res. 1992; 11(2):147-50. DOI: 10.1016/0920-1211(92)90049-y. View

17.

Watkins P, Seeff L . Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology. 2006; 43(3):618-31. DOI: 10.1002/hep.21095. View

18.

Cover C, Liu J, Farhood A, Malle E, Waalkes M, Bajt M . Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol. 2006; 216(1):98-107. DOI: 10.1016/j.taap.2006.04.010. View

19.

Gunawan B, Liu Z, Han D, Hanawa N, Gaarde W, Kaplowitz N . c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006; 131(1):165-78. DOI: 10.1053/j.gastro.2006.03.045. View

20.

Yin H, Kim M, Kim J, Kong G, Lee M, Kang K . Hepatic gene expression profiling and lipid homeostasis in mice exposed to steatogenic drug, tetracycline. Toxicol Sci. 2006; 94(1):206-16. DOI: 10.1093/toxsci/kfl078. View