Immunoglobulin Profile and Lymphocyte Subsets in Preterm Neonates

Overview

Journal Indian Pediatr

Specialty Pediatrics

Date 2022 Jan 7

PMID 34992185

Authors

Rahul Sharma

Kanya Mukhopadhyay

Amit Rawat

Vanita Suri

Surjit Singh

Affiliations

Soon will be listed here.

Abstract

Objective: We documented the immunological profile of neonates and mothers, and lymphocyte subsets at birth.

Methods: Consecutively born preterm neonates (26 to 31 weeks gestation) at our level III neonatal unit, fulfilling the inclusion criteria were enrolled. Immunoglobulin levels were assessed in maternal blood and in cord blood along with T cell subsets.

Results: A total of 115 neonates were enrolled. The mean cord levels for IgG, IgM and IgA, respectively were 5.34, 0.10 and 0.04 g/L and of B, T, NK and NK-T cells were 14%, 71%, 10% and 1%, respectively of total lymphocyte population. Cord IgG and IgA levels showed a significantly rising trend with increasing gestation (P=0.005 and 0.02, respectively) but not IgM and T cell subsets. Maternal immunoglobulins were similar in all gestations.

Conclusion: The cord IgG and IgA increased with increasing gestation but not IgM in neonates.

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