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Falciparum Malaria Associated Acute Kidney Injury with Polyneuropathy and Intra-arterial Thrombosis (stroke)

Overview
Journal Eur J Med Res
Publisher Biomed Central
Specialty General Medicine
Date 2022 Jan 7
PMID 34991710
Citations 2
Authors
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Abstract

Background: Malaria is still major problem in developing countries, such as Pakistan. Besides fever, body ache and vomiting it can present with acute kidney injury, proteinuria, hematuria and cerebral manifestations which are more common with falciparum malaria. Neurological manifestations are rare presentation of malaria and should be consider in patients who are admitting with features of neuropathy and stroke.

Case Presentation: We describe an unusual case of falciparum malaria, complicated by acute kidney injury who developed Polyneuropathy and intra-arterial thrombosis in middle cerebral artery territory. Our patient recovered his renal functions during admission and recovered his power and sensation in his limbs as well after 1 month.

Conclusion: Malaria cause neurological manifestations including axonal and sensory neuropathy, cerebral venous and arterial thrombosis, PMNS, cerebellar signs and symptoms, psychosis, etc. With prompt diagnosis and early treatment they can be cure and regain their motor and sensory functions to normal level.

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References
1.
Kute V, Trivedi H, Vanikar A, Shah P, Gumber M, Kanodia K . Collapsing glomerulopathy and hemolytic uremic syndrome associated with falciparum malaria: completely reversible acute kidney injury. J Parasit Dis. 2014; 37(2):286-90. PMC: 3793102. DOI: 10.1007/s12639-012-0164-6. View

2.
Khattak A, Venkatesan M, Nadeem M, Satti H, Yaqoob A, Strauss K . Prevalence and distribution of human Plasmodium infection in Pakistan. Malar J. 2013; 12:297. PMC: 3765785. DOI: 10.1186/1475-2875-12-297. View

3.
Idro R, Jenkins N, Newton C . Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol. 2005; 4(12):827-40. DOI: 10.1016/S1474-4422(05)70247-7. View

4.
Plewes K, Kingston H, Ghose A, Maude R, Herdman M, Leopold S . Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study. BMC Infect Dis. 2017; 17(1):313. PMC: 5408414. DOI: 10.1186/s12879-017-2373-1. View

5.
Walker A, Ellis J, Irama M, Senkungu J, Nansera D, Axton J . Eosinophilic glomerulonephritis in children in Southwestern Uganda. Kidney Int. 2007; 71(6):569-73. DOI: 10.1038/sj.ki.5002085. View