Association Study of MiR-149, MiR-196a2, and MiR-499a Polymorphisms with Coronary Artery Aneurysm of Kawasaki Disease in Southern Chinese Population

Overview

Journal J Gene Med

Specialties Genetics
Molecular Biology

Date 2021 Dec 30

PMID 34969167

Citations 2

Authors

Lanyan Fu

Yufen Xu

Hongyan Yu

Lei Pi

Jinqing Li

Huazhong Zhou

Li Zhang

Tingfang Zhang

Di Che

Xiaoqiong Gu

Affiliations

Soon will be listed here.

Abstract

Background: Accumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with disease susceptibility or progression, such as in Kawasaki disease (KD). Our previous studies revealed the association of miR-149 rs2292832 T>C and miR-196a2 rs11614913 C>T polymorphisms with KD susceptibility. The present study further focused on the relationship between three miRNA polymorphisms (miR-149 rs2292832 T>C, miR-196a2 rs11614913 C>T and miR-499a rs3746444 A>G) and the risk of coronary artery aneurysm (CAA) in southern Chinese KD patients.

Methods: We evaluated 318 KD patients with CAAs and 784 patients without CAAs. TaqMan assays were used to estimate genotyping and analyze the relationship between miRNA polymorphisms (miR-149 rs2292832 T>C, miR-196a2 rs11614913 C>T and miR-499a rs3746444 A>G) and risk associations of CAA by odds ratios (ORs) and 95% confidence intervals (CIs).

Results: We found that the miR-149 rs2292832 TC/CC genotype increased the CAA risk (adjusted OR = 1.53, 95% CI = 1.15-2.03, p = 0.003 for TC, adjusted OR = 1.63, 95% CI = 1.08-2.47, p = 0.021 for CC), whereas the miR-499a rs3746444 AG genotype decreased the CAA risk in KD patients (adjusted OR = 0.33, 95% CI = 0.25-0.45 p ≤ 0.001). Moreover, patients carrying two or three of these single nucleotide polymorphism (SNP) genotypes (rs2292832 TC/CC and rs11614913 TT and rs3746444 AA) had a higher risk for CAA than those who harbored only zero or one of these SNP genotypes.

Conclusions: Our results demonstrated that the miR-149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients. Further studies with larger sample sizes and different centers are needed to confirm the findings of the present study.

Citing Articles

MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring.

Xiong Y, Xu J, Zhang D, Wu S, Li Z, Zhang J Front Immunol. 2022; 13:1016575.

PMID: 36353615 PMC: 9638168. DOI: 10.3389/fimmu.2022.1016575.

Association study of miR-149, miR-196a2, and miR-499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population.

Fu L, Xu Y, Yu H, Pi L, Li J, Zhou H J Gene Med. 2021; 24(4):e3405.

PMID: 34969167 PMC: 9286670. DOI: 10.1002/jgm.3405.

References

Li J, Wang J, Su X, Jiang Z, Rong X, Gu X . Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population. J Clin Lab Anal. 2019; 34(4):e23125. PMC: 7171309. DOI: 10.1002/jcla.23125. View

Pi L, Fu L, Xu Y, Che D, Deng Q, Huang X . Lack of association between rs11134527 A>G and Kawasaki disease susceptibility. Biosci Rep. 2018; 38(3). PMC: 6048205. DOI: 10.1042/BSR20180367. View

Zhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z . Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis. Circ Res. 2020; 127(7):855-873. PMC: 7486265. DOI: 10.1161/CIRCRESAHA.120.316951. View

Hashemi M, Eskandari-Nasab E, Zakeri Z, Atabaki M, Bahari G, Jahantigh M . Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis. Mol Med Rep. 2012; 7(1):287-91. DOI: 10.3892/mmr.2012.1176. View

Kumrah R, Vignesh P, Rawat A, Singh S . Immunogenetics of Kawasaki disease. Clin Rev Allergy Immunol. 2020; 59(1):122-139. DOI: 10.1007/s12016-020-08783-9. View

Agiannitopoulos K, Samara P, Papadopoulou M, Efthymiadou A, Papadopoulou E, Tsaousis G . miRNA polymorphisms and risk of premature coronary artery disease. Hellenic J Cardiol. 2020; 62(4):278-284. DOI: 10.1016/j.hjc.2020.01.005. View

Latini A, Ciccacci C, Novelli G, Borgiani P . Polymorphisms in miRNA genes and their involvement in autoimmune diseases susceptibility. Immunol Res. 2017; 65(4):811-827. DOI: 10.1007/s12026-017-8937-8. View

Wang J, Li J, Qiu H, Zeng L, Zheng H, Rong X . Association between miRNA-196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children. J Clin Lab Anal. 2019; 33(7):e22925. PMC: 6757130. DOI: 10.1002/jcla.22925. View

Sosa T, Brower L, Divanovic A . Diagnosis and Management of Kawasaki Disease. JAMA Pediatr. 2019; 173(3):278-279. DOI: 10.1001/jamapediatrics.2018.3307. View

10.

Toraih E, Ismail N, Toraih A, Hussein M, Fawzy M . Precursor miR-499a Variant but not miR-196a2 is Associated with Rheumatoid Arthritis Susceptibility in an Egyptian Population. Mol Diagn Ther. 2016; 20(3):279-95. DOI: 10.1007/s40291-016-0194-3. View

11.

Xu B, Luo X, Ning X, Luo J, Guo J, Liu Q . miR-149 rs2292832 C allele enhances the cytotoxic effect of temozolomide against glioma cells. Neuroreport. 2020; 31(6):498-506. DOI: 10.1097/WNR.0000000000001440. View

12.

Wang Y, Lu Z, Fu L, Tan Y, Che D, Huang P . The rs4919510 G>C polymorphism confers reduce coronary injury of Kawasaki disease in a Southern Chinese population. Biosci Rep. 2019; 39(5). PMC: 6522709. DOI: 10.1042/BSR20181660. View

13.

Wang Y, Lian X, Zhong J, Su S, Xu Y, Xie X . Serum exosomal microRNA let-7i-3p as candidate diagnostic biomarker for Kawasaki disease patients with coronary artery aneurysm. IUBMB Life. 2019; 71(7):891-900. DOI: 10.1002/iub.2015. View

14.

Li Q, Chen L, Chen D, Wu X, Chen M . Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease. Am J Transl Res. 2015; 7(2):393-400. PMC: 4399102. View

15.

Huang Y, Lin K, Ho S, Yan J, Lo M, Kuo H . Increased Incidence of Kawasaki Disease in Taiwan in Recent Years: A 15 Years Nationwide Population-Based Cohort Study. Front Pediatr. 2019; 7:121. PMC: 6450208. DOI: 10.3389/fped.2019.00121. View

16.

Liu P, Zhuo Z, Zhu J, Yang Z, Xin Y, Li S . Association of TP53 rs1042522 C>G and miR-34b/c rs4938723 T>C polymorphisms with hepatoblastoma susceptibility: A seven-center case-control study. J Gene Med. 2020; 22(7):e3182. DOI: 10.1002/jgm.3182. View

17.

Newburger J, Takahashi M, Gerber M, Gewitz M, Tani L, Burns J . Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart.... Circulation. 2004; 110(17):2747-71. DOI: 10.1161/01.CIR.0000145143.19711.78. View

18.

Sung J, Kim S, Yang W, Kim W, Moon J, Kim I . miRNA polymorphisms (miR‑146a, miR‑149, miR‑196a2 and miR‑499) are associated with the risk of coronary artery disease. Mol Med Rep. 2016; 14(3):2328-42. DOI: 10.3892/mmr.2016.5495. View

19.

Fu L, Xu Y, Yu H, Pi L, Li J, Zhou H . Association study of miR-149, miR-196a2, and miR-499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population. J Gene Med. 2021; 24(4):e3405. PMC: 9286670. DOI: 10.1002/jgm.3405. View

20.

Rowley A, Shulman S . The Epidemiology and Pathogenesis of Kawasaki Disease. Front Pediatr. 2019; 6:374. PMC: 6298241. DOI: 10.3389/fped.2018.00374. View