Integrative Approaches in Genome Structure Analysis

Overview

Journal Structure

Publisher Cell Press

Specialties Biochemistry
Biotechnology
Cell Biology
Molecular Biology

Date 2021 Dec 28

PMID 34963059

Citations 5

Authors

Lorenzo Boninsegna

Asli Yildirim

Yuxiang Zhan

Frank Alber

Affiliations

Soon will be listed here.

Abstract

New technological advances in integrated imaging, sequencing-based assays, and computational analysis have revolutionized our view of genomes in terms of their structure and dynamics in space and time. These advances promise a deeper understanding of genome functions and mechanistic insights into how the nucleus is spatially organized and functions. These wide arrays of complementary data provide an opportunity to produce quantitative integrative models of nuclear organization. In this article, we highlight recent key developments and discuss the outlook for these fields.

Citing Articles

Unveiling the role of chromosome structure morphology on gene function through chromosome conformation analysis.

Zhan Y, Yildirim A, Boninsegna L, Alber F Genome Biol. 2025; 26(1):30.

PMID: 39948644 PMC: 11827233. DOI: 10.1186/s13059-024-03472-8.

Computational methods for analysing multiscale 3D genome organization.

Zhang Y, Boninsegna L, Yang M, Misteli T, Alber F, Ma J Nat Rev Genet. 2023; 25(2):123-141.

PMID: 37673975 PMC: 11127719. DOI: 10.1038/s41576-023-00638-1.

Studying the impact of the nuclear topography on gene function.

Nat Struct Mol Biol. 2023; 30(8):1062-1063.

PMID: 37596467 DOI: 10.1038/s41594-023-01051-2.

Large-scale data-driven and physics-based models offer insights into the relationships among the structures, dynamics, and functions of chromosomes.

Feng C, Wang J, Chu X J Mol Cell Biol. 2023; 15(6).

PMID: 37365687 PMC: 10782906. DOI: 10.1093/jmcb/mjad042.

Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants.

Zhong W, Liu W, Chen J, Sun Q, Hu M, Li Y Front Cell Dev Biol. 2022; 10:957292.

PMID: 36060805 PMC: 9437546. DOI: 10.3389/fcell.2022.957292.

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