Exosome MicroRNAs in Metabolic Syndrome As Tools for the Early Monitoring of Diabetes and Possible Therapeutic Options

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2021 Dec 28

PMID 34959658

Citations 16

Authors

Erika Cione

Roberto Cannataro

Luca Gallelli

Giovambattista De Sarro

Maria Cristina Caroleo

Affiliations

Soon will be listed here.

Abstract

Exosomes are nano-sized extracellular vesicles produced and released by almost all cell types. They play an essential role in cell-cell communications by delivering cellular bioactive compounds such as functional proteins, metabolites, and nucleic acids, including microRNA, to recipient cells. Thus, they are involved in various physio-pathological conditions. Exosome-miRNAs are associated with numerous diseases, including type 2 diabetes, a complex multifactorial metabolic disorder linked to obesity. In addition, exosome-miRNAs are emerging as essential regulators in the progression of diabetes, principally for pancreatic β-cell injury and insulin resistance. Here, we have clustered the recent findings concerning exosome-miRNAs associated with β-cell dysfunction to provide a novel approach for the early diagnosis and therapy of diabetes.

Citing Articles

Special Issue "Adipose Tissue Diseases: Physiopathology, Molecular Mechanism, Diagnosis, and Treatment".

Cannataro R, Michelini S, Cione E Int J Mol Sci. 2025; 26(5).

PMID: 40076692 PMC: 11900491. DOI: 10.3390/ijms26052068.

Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease.

Malaguarnera M, Cauli O, Cabrera-Pastor A Biomolecules. 2025; 15(2).

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Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice.

Yang Y, Chen Y, Liu C, Wang S, Zhao Y, Cao W J Diabetes Res. 2025; 2025():6251747.

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Exosome-based drug delivery systems for the treatment of diabetes and its complications: current opinion.

Chen Q, Chen J, Liu Y, Qi S, Huang L Extracell Vesicles Circ Nucl Acids. 2024; 4(3):502-517.

PMID: 39698026 PMC: 11648477. DOI: 10.20517/evcna.2023.32.

Identification of Specific microRNAs in Adipose Tissue Affected by Lipedema.

Cione E, Michelini S, Abrego-Guandique D, Vaia N, Michelini S, Puleo V Curr Issues Mol Biol. 2024; 46(11):11957-11974.

PMID: 39590304 PMC: 11592672. DOI: 10.3390/cimb46110710.

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