Ketogenic Diet and MicroRNAs Linked to Antioxidant Biochemical Homeostasis

Overview

Journal Antioxidants (Basel)

Date 2019 Aug 7

PMID 31382449

Citations 32

Authors

Roberto Cannataro

Maria Cristina Caroleo

Alessia Fazio

Chiara La Torre

Pierluigi Plastina

Luca Gallelli

Graziantonio Lauria

Erika Cione

Affiliations

Soon will be listed here.

Abstract

Recently, we demonstrated the capability of the ketogenic diet (KD) to influence the microRNA (miR) expression profile. Here, we report that KD is able to normalize miR expression in obese subjects when compared with lean subjects. By applying two different bioinformatics tools, we found that, amongst the miRs returning to comparable levels in lean subjects, four of them are linked to antioxidant biochemical pathways specifically, and the others are linked to both antioxidant and anti-inflammatory biochemical pathways. Of particular interest is the upregulation of hsa-miR-30a-5p, which correlates with the decrease of catalase expression protein in red blood cells.

Citing Articles

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Abrego-Guandique D, Cione E, Caroleo M, Bonilla D, Cannataro R Front Nutr. 2025; 12:1545832.

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miRNA Signatures in Alveolar Macrophages Related to Cigarette Smoke: Assessment and Bioinformatics Analysis.

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