Prostate Microbiota and Prostate Cancer: A New Trend in Treatment

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Dec 27

PMID 34956913

Citations 19

Authors

Bangwei Che

Wenjun Zhang

Shenghan Xu

Jingju Yin

Jun He

Tao Huang

Wei Li

Ying Yu

Kaifa Tang

Affiliations

Soon will be listed here.

Abstract

Although the incidence and mortality of prostate cancer have gradually begun to decline in the past few years, it is still one of the leading causes of death from malignant tumors in the world. The occurrence and development of prostate cancer are affected by race, family history, microenvironment, and other factors. In recent decades, more and more studies have confirmed that prostate microflora in the tumor microenvironment may play an important role in the occurrence, development, and prognosis of prostate cancer. Microorganisms or their metabolites may affect the occurrence and metastasis of cancer cells or regulate anti-cancer immune surveillance. In addition, the use of tumor microenvironment bacteria in interventional targeting therapy of tumors also shows a unique advantage. In this review, we introduce the pathway of microbiota into prostate cancer, focusing on the mechanism of microorganisms in tumorigenesis and development, as well as the prospect and significance of microorganisms as tumor biomarkers and tumor prevention and treatment.

Citing Articles

Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer.

Trecarten S, Liss M, Hamilton-Reeves J, DiGiovanni J Front Immunol. 2025; 15():1448116.

PMID: 39840030 PMC: 11747771. DOI: 10.3389/fimmu.2024.1448116.

Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota.

Chen L, Xu Y, Wang Y, Ren Y, Dong X, Wu P Mol Cancer. 2024; 23(1):229.

PMID: 39395984 PMC: 11470719. DOI: 10.1186/s12943-024-02137-1.

Gut dysbiosis impacts the immune system and promotes prostate cancer.

Shyanti R, Greggs J, Malik S, Mishra M Immunol Lett. 2024; 268:106883.

PMID: 38852888 PMC: 11249078. DOI: 10.1016/j.imlet.2024.106883.

From microbes to medicine: harnessing the gut microbiota to combat prostate cancer.

Yadav A, Kaushik M, Tiwari P, Dada R Microb Cell. 2024; 11:187-197.

PMID: 38803512 PMC: 11129862. DOI: 10.15698/mic2024.05.824.

Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review.

Liu G, Yao Z, Chen G, Li Y, Liang B Chin J Integr Med. 2024; 30(11):1045-1055.

PMID: 38561489 DOI: 10.1007/s11655-024-4100-2.

References

Ou T, Zhou Z, Turner D, Zhu B, Lilly M, Jiang W . Increased Preoperative Plasma Level of Microbial 16S rDNA Translocation Is Associated With Relapse After Prostatectomy in Prostate Cancer Patients. Front Oncol. 2020; 9:1532. PMC: 6974797. DOI: 10.3389/fonc.2019.01532. View

Abedi S, Doosti A, Jami M . Impacts of the prostate stem cell antigen (PSCA) and enterotoxin (CPE) on the apoptosis and cell cycle regulatory genes in PC3. Prep Biochem Biotechnol. 2019; 50(1):47-55. DOI: 10.1080/10826068.2019.1660892. View

Bardia A, Platz E, Yegnasubramanian S, De Marzo A, Nelson W . Anti-inflammatory drugs, antioxidants, and prostate cancer prevention. Curr Opin Pharmacol. 2009; 9(4):419-26. PMC: 4479123. DOI: 10.1016/j.coph.2009.06.002. View

Yun S, Jeong P, Kang H, Kim Y, Kim E, Yan C . Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers. Int Neurourol J. 2015; 19(2):74-84. PMC: 4490318. DOI: 10.5213/inj.2015.19.2.74. View

Balzan S, de Almeida Quadros C, de Cleva R, Zilberstein B, Cecconello I . Bacterial translocation: overview of mechanisms and clinical impact. J Gastroenterol Hepatol. 2007; 22(4):464-71. DOI: 10.1111/j.1440-1746.2007.04933.x. View

Rezaei S, Hayward J, Norden S, Pedersen J, Mills J, Hearps A . HERV-K Gag RNA and Protein Levels Are Elevated in Malignant Regions of the Prostate in Males with Prostate Cancer. Viruses. 2021; 13(3). PMC: 7999808. DOI: 10.3390/v13030449. View

Oh T, Kim S, Caussy C, Fu T, Guo J, Bassirian S . A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020; 32(5):901. PMC: 7891106. DOI: 10.1016/j.cmet.2020.10.015. View

Breyer B, Jiang W, Cheng H, Zhou L, Paul R, Feng T . Adenoviral vector-mediated gene transfer for human gene therapy. Curr Gene Ther. 2002; 1(2):149-62. DOI: 10.2174/1566523013348689. View

Qu H, Xia Y, Li X . Recombinant Human p53 Adenovirus Injection (rAd-p53) Combined with Chemotherapy for 4 Cases of High-grade Serous Ovarian Cancer. Curr Gene Ther. 2020; 20(4):313-320. DOI: 10.2174/1566523220666200826100245. View

10.

Bae Y, Ito T, Iida T, Uchida K, Sekine M, Nakajima Y . Intracellular Propionibacterium acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer. PLoS One. 2014; 9(2):e90324. PMC: 3938683. DOI: 10.1371/journal.pone.0090324. View

11.

Cossart P, Sansonetti P . Bacterial invasion: the paradigms of enteroinvasive pathogens. Science. 2004; 304(5668):242-8. DOI: 10.1126/science.1090124. View

12.

Poole N, Green S, Rajan A, Vela L, Zeng X, Estes M . Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun. 2017; 85(11). PMC: 5649017. DOI: 10.1128/IAI.00581-17. View

13.

Polk D, Peek Jr R . Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer. 2010; 10(6):403-14. PMC: 2957472. DOI: 10.1038/nrc2857. View

14.

Kistowska M, Meier B, Proust T, Feldmeyer L, Cozzio A, Kuendig T . Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients. J Invest Dermatol. 2014; 135(1):110-118. DOI: 10.1038/jid.2014.290. View

15.

Hooton T, Bradley S, Cardenas D, Colgan R, Geerlings S, Rice J . Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010; 50(5):625-63. DOI: 10.1086/650482. View

16.

Crocetto F, Boccellino M, Barone B, Di Zazzo E, Sciarra A, Galasso G . The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?. Nutrients. 2020; 12(9). PMC: 7551491. DOI: 10.3390/nu12092648. View

17.

Ishii K, Sasaki T, Iguchi K, Kajiwara S, Kato M, Kanda H . Interleukin-6 induces VEGF secretion from prostate cancer cells in a manner independent of androgen receptor activation. Prostate. 2018; 78(11):849-856. DOI: 10.1002/pros.23643. View

18.

Fassi Fehri L, Mak T, Laube B, Brinkmann V, Ogilvie L, Mollenkopf H . Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells. Int J Med Microbiol. 2010; 301(1):69-78. DOI: 10.1016/j.ijmm.2010.08.014. View

19.

Lawal O, Barata M, Fraqueza M, Worning P, Bartels M, Goncalves L . From Clinical and Environmental Origins Have Distinct Biofilm Composition. Front Microbiol. 2021; 12:663768. PMC: 8216562. DOI: 10.3389/fmicb.2021.663768. View

20.

Flavell R, Sanjabi S, Wrzesinski S, Licona-Limon P . The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol. 2010; 10(8):554-67. PMC: 3885992. DOI: 10.1038/nri2808. View