A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525

Overview

Journal Nanomaterials (Basel)

Date 2021 Dec 24

PMID 34947655

Citations 4

Authors

Yuzhu He

Yuanyuan Li

Enjun Zuo

Songling Chai

Xiang Ren

Tao Fei

Guowu Ma

Xiumei Wang

Huiying Liu

Affiliations

Soon will be listed here.

Abstract

For the benefit of antibacterial Ti on orthopedic and dental implants, a bioactive coating (Pac@PLGA MS/HA coated Ti) was deposited on the surface of pure titanium (Ti), which included two layers: an acid-alkali heat pretreated biomimetic mineralization layer and an electrosprayed Poly (D,L-lactide-co- glycolic acid) (PLGA) microsphere layer as a sustained-release system. Hydroxyapatite (HA) in mineralization layer was primarily prepared on the Ti followed by the antibacterial coating of Pac-525 loaded by PLGA microspheres. After observing the antimicrobial peptides distributed uniformly on the titanium surface, the release assay showed that the release of Pac-525 from Pac@PLGA MS/HA coated Ti provided a large initial burst followed by a slow release at a flat rate. Pac@PLGA MS/HA coated Ti exhibited a strong cytotoxicity to both Gram-negative bacteria () and Gram-positive bacteria (). In addition, Pac@PLGA MS/HA coated Ti did not affect the growth and adhesion of the osteoblast-like cell line, MC3T3-E1. These data suggested that a bionic mineralized composite coating with long-term antimicrobial activity was successfully prepared.

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