Mechanochemical Grignard Reactions with Gaseous CO and Sodium Methyl Carbonate

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2021 Dec 23

PMID 34942056

Citations 13

Authors

Victoria S Pfennig

Romina C Villella

Julia Nikodemus

Carsten Bolm

Affiliations

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Abstract

A one-pot, three-step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO ) or sodium methyl carbonate providing aryl and alkyl carboxylic acids in up to 82 % yield is reported. Noteworthy are the short reaction times and the significantly reduced solvent amounts [2.0 equiv. for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to symmetric ketones as major products.

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