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Calcitonin Gene Related Peptide Stimulates Adenylate Cyclase Activity in Rat Striated Muscle

Overview
Journal Experientia
Specialty Science
Date 1987 Mar 15
PMID 3493916
Citations 8
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Abstract

Rat calcitonin gene related peptide (CGRP) and salmon calcitonin (CT) stimulated adenylate cyclase activity in a dose-dependent manner in the rat diaphragm and in the kidney. The ED50 value of rat CGRP was lower and that of salmon CT was higher in the diaphragm than in the kidney. These results suggest that CGRP stimulates adenylate cyclase activity in the striated muscle by reacting with sites distinct from the site in the kidney.

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