Regulation of Nicotinic Acetylcholine Receptors by Protein Phosphorylation

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 1988 Jan 1

PMID 3077316

Citations 5

Authors

K Miles

R L Huganir

Affiliations

Soon will be listed here.

Abstract

Neurotransmitter receptors and ion channels play a critical role in the transduction of signals at chemical synapses. The modulation of neurotransmitter receptor and ion channel function by protein phosphorylation is one of the major regulatory mechanisms in the control of synaptic transmission. The nicotinic acetylcholine receptor (nAcChR) has provided an excellent model system in which to study the modulation of neurotransmitter receptors and ion channels by protein phosphorylation since the structure and function of this receptor have been so extensively characterized. In this article, the structure of the nAcChR from the electric organ of electric fish, skeletal muscle, and the central and peripheral nervous system will be briefly reviewed. Emphasis will be placed on the regulation of the phosphorylation of nAcChR by second messengers and by neurotransmitters and hormones. In addition, recent studies on the functional modulation of nicotinic receptors by protein phosphorylation will be reviewed.

Citing Articles

PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice.

Valenzuela I, Pires-Oliveira M, Akaaboune M PLoS One. 2013; 8(11):e81311.

PMID: 24260568 PMC: 3829966. DOI: 10.1371/journal.pone.0081311.

Neural influence on protein kinase C isoform expression in skeletal muscle.

Hilgenberg L, Yearwood S, MILSTEIN S, Miles K J Neurosci. 1996; 16(16):4994-5003.

PMID: 8756430 PMC: 6579314.

Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.

Schubert U, Strebel K J Virol. 1994; 68(4):2260-71.

PMID: 8139011 PMC: 236702. DOI: 10.1128/JVI.68.4.2260-2271.1994.

Assembly of Torpedo acetylcholine receptors in Xenopus oocytes.

Saedi M, Conroy W, Lindstrom J J Cell Biol. 1991; 112(5):1007-15.

PMID: 1999453 PMC: 2288882. DOI: 10.1083/jcb.112.5.1007.

Nicotinic receptor-associated 43K protein and progressive stabilization of the postsynaptic membrane.

Hill Jr J Mol Neurobiol. 1992; 6(1):1-17.

PMID: 1463586 DOI: 10.1007/BF02935564.

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