Staphylococcus Aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine Following Induction by Mupirocin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2021 Dec 21

PMID 34930023

Citations 7

Authors

Q C Truong-Bolduc

Y Wang

J L Reedy

J M Vyas

D C Hooper

Affiliations

Soon will be listed here.

Abstract

Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and , respectively.

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