Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2021 Dec 20

PMID 34926636

Citations 13

Authors

Lei Zhang

Fenghong Wang

Gong Gao

Xiaochun Yan

Hongfu Liu

Zhihong Liu

Zhixin Wang

Libing He

Qi Lv

Zhiying Wang

Ruijun Wang

Yanjun Zhang

Jinquan Li

Rui Su

Affiliations

Soon will be listed here.

Abstract

Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW). In this study, a genome-wide association study (GWAS) of BW, WW, and YW was determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats. We discovered that 21 SNPs were significantly associated with BW on the genome-wide levels. These SNPs were located in 10 genes, e.g., Mitogen-Activated Protein Kinase 3 (), LIM domain binding 2 (), and low-density lipoprotein receptor-related protein 1B (), which may be related to muscle growth and development in Inner Mongolia Cashmere goats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were significantly enriched in the regulation of actin cytoskeleton and phospholipase D signaling pathway etc. In summary, this study will improve the marker-assisted breeding of Inner Mongolia cashmere goats and the molecular mechanisms of important economic traits.

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