An Update of Advanced Nanoplatforms for Glioblastoma Multiforme Management

Overview

Journal EXCLI J

Specialty Biology

Date 2021 Dec 20

PMID 34924904

Citations 9

Authors

Mariana Amaral

Nuno Cruz

Ana Rosa

Beatriz Nogueira

Diana Costa

Francisco Santos

Mariana Brazao

Pedro Policarpo

Rita Mateus

Yan Kobozev

Catarina Pinto Reis

Affiliations

Soon will be listed here.

Abstract

Glioblastoma multiforme (GBM) is a very aggressive and heterogeneous glioma. Currently, GBM is treated with a combination of surgery, radiotherapy, chemotherapy (e.g. temozolamide) and Tumour Treating Fields. Unfortunately, the mean survival is still around 15 months. This poor prognosis is associated with therapy resistance, tumor recurrence, and limited delivery of drugs due to the blood-brain barrier nature. Nanomedicine, the application of nanotechnology to medicine, has revolutionized many health fields, specifically cancer diagnosis and treatment. This review explores the particularities of different nanosystems (i.e., superparamagnetic, polymeric and gold nanoparticles, and liposomes) as well as how they can be applied to the treatment and diagnosis of GBM. As described, the most of the cited examples are on the preclinical phase; however, positive results were obtained and thus, the distance to achieve an effective treatment is shorter every day.

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