Epithelial Colonization by Gut Dendritic Cells Promotes Their Functional Diversification

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2021 Dec 15

PMID 34910930

Citations 19

Authors

Claudia A Rivera

Violaine Randrian

Wilfrid Richer

Yohan Gerber-Ferder

Maria-Graciela Delgado

Aleksandra S Chikina

Annika Frede

Chiara Sorini

Mathieu Maurin

Hana Kammoun-Chaari

Sara M Parigi

Christel Goudot

Mar Cabeza-Cabrerizo

Sylvain Baulande

Sonia Lameiras

Pierre Guermonprez

Caetano Reis e Sousa

Marc Lecuit

Helene D Moreau

Julie Helft

Danijela Matic Vignjevic

Eduardo J Villablanca

Ana-Maria Lennon-Dumenil

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets that can exhibit different activation states and functions. How tissue-specific cues orchestrate DC diversification remains elusive. Here, we show that the small intestine included two pools of cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) CD103CD11b cDC2s that were mature-like proinflammatory cells and (2) intraepithelial cDC2s that exhibited an immature-like phenotype as well as tolerogenic properties. These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium. There, cDC2s were imprinted by environmental cues, including ATRA itself and the mucus component Muc2. Hence, by reaching distinct subtissular niches, DCs can exist as immature and mature cells within the same tissue, revealing an additional mechanism of DC functional diversification.

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