M Cell Maturation and CDC Activation Determine the Onset of Adaptive Immune Priming in the Neonatal Peyer's Patch

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2023 May 2

PMID 37130522

Authors

Natalia Torow

Ronghui Li

Thomas Charles Adrian Hitch

Clemens Mingels

Shahed Al Bounny

Niels van Best

Eva-Lena Stange

Britta Simons

Tiago Maie

Lennart Ruttger

Narasimha Murthy Keshava Prasad Gubbi

Darryl Adelaide Abbott

Adam Benabid

Michael Gadermayr

Solveig Runge

Nicole Treichel

Dorit Merhof

Stephan Patrick Rosshart

Nico Jehmlich

Timothy Wesley Hand

Martin von Bergen

Felix Heymann

Oliver Pabst

Thomas Clavel

Frank Tacke

Hugues Lelouard

Ivan Gesteira Costa

Mathias Walter Hornef

Affiliations

Soon will be listed here.

Abstract

Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ antigen-presenting cells (RORgt+ APC) exhibited significant age-dependent changes in subset composition, tissue distribution, and reduced cell maturation, subsequently resulting in a lack in CD4+ T cell priming during the postnatal period. Microbial cues contributed but could not fully explain the discrepancies in MNP maturation. Type I interferon (IFN) accelerated MNP maturation but IFN signaling did not represent the physiological stimulus. Instead, follicle-associated epithelium (FAE) M cell differentiation was required and sufficient to drive postweaning PP MNP maturation. Together, our results highlight the role of FAE M cell differentiation and MNP maturation in postnatal immune development.

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