Patho-mechanisms of the Origins of Bronchopulmonary Dysplasia

Overview

Journal Mol Cell Pediatr

Publisher Springer

Specialty Pediatrics

Date 2021 Dec 11

PMID 34894313

Citations 11

Authors

Mitali Sahni

Vineet Bhandari

Affiliations

Soon will be listed here.

Abstract

Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications of prematurity, despite significant advancement in neonatology over the last couple of decades. The new BPD is characterized histopathologically by impaired lung alveolarization and dysregulated vascularization. With the increased survival of extremely preterm infants, the risk for the development of BPD remains high, emphasizing the continued need to understand the patho-mechanisms that play a role in the development of this disease. This brief review summarizes recent advances in our understanding of the maldevelopment of the premature lung, highlighting recent research in pathways of oxidative stress-related lung injury, the role of placental insufficiency, growth factor signaling, the extracellular matrix, and microRNAs.

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