Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2021 Dec 10

PMID 34888399

Citations 14

Authors

Renee A Pond

Lauren F Collins

Cecile D Lahiri

Affiliations

Soon will be listed here.

Abstract

Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS comorbidities (NACMs); emerging evidence suggests that women are at higher risk of NACM development and progression compared with men. It is widely recognized that women vs men have greater immune activation in response to many viruses, including HIV-1; this likely influences sex-differential NACM development related to differences in HIV-associated chronic inflammation. Furthermore, many sociobehavioral factors that contribute to aging-related NACMs are known to differ by sex. The objectives of this review were to (1) synthesize sex-stratified data on 4 NACMs among PWH: bone disease, cardiovascular disease, metabolic dysfunction, and neurocognitive impairment; (2) evaluate the characteristics of key studies assessing sex differences in NACMs; and (3) introduce potential biological and psychosocial mechanisms contributing to emerging trends in sex-differential NACM risk and outcomes among PWH.

Citing Articles

Disproportionate Vulnerability to and Unique Aggregation Pattern of Non-AIDS Comorbidities Among Women With HIV in China.

Chen X, Guo C, Wang T, Shen W, Wang S, Wang Y Open Forum Infect Dis. 2025; 12(2):ofaf046.

PMID: 39935963 PMC: 11811902. DOI: 10.1093/ofid/ofaf046.

Cytokine trajectory over time in men and women with HIV on long-term antiretroviral therapy.

Vanpouille C, Wells A, DeGruttola V, Lynch M, Zhang X, Fitzgerald W AIDS. 2024; 39(1):1-10.

PMID: 39639719 PMC: 11631044. DOI: 10.1097/QAD.0000000000004033.

Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV.

Alvarez J, Yang C, Ojuri V, Buckley K, Bedi B, Musonge-Effoe J Curr HIV/AIDS Rep. 2024; 22(1):3.

PMID: 39570329 PMC: 11773452. DOI: 10.1007/s11904-024-00711-2.

Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV.

Kaur H, Alluri R, Wu K, Kalayjian R, Bush W, Palella F Antioxidants (Basel). 2024; 13(9).

PMID: 39334701 PMC: 11429126. DOI: 10.3390/antiox13091042.

The impact of sex on HIV immunopathogenesis and therapeutic interventions.

Mihealsick E, Word A, Scully E J Clin Invest. 2024; 134(18).

PMID: 39286972 PMC: 11405047. DOI: 10.1172/JCI180075.

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