Tuning Receptor Properties of Metal-Amyloid Beta Complexes. Studies on the Interaction Between Ni(II)-Aβ and Phosphates/Nucleotides

Overview

Journal Inorg Chem

Specialty Chemistry

Date 2021 Dec 8

PMID 34878265

Authors

Aleksandra Tobolska

Nina E Wezynfeld

Urszula E Wawrzyniak

Wojciech Bal

Wojciech Wroblewski

Affiliations

Soon will be listed here.

Abstract

Amyloid-beta (Aβ) peptides, potentially relevant in the pathology of Alzheimer's disease, possess distinctive coordination properties, enabling an effective binding of transition-metal ions, with a preference for Cu(II). In this work, we found that a N-truncated Aβ analogue bearing a His-2 motif, Aβ, forms a stable Ni(II) high-spin octahedral complex at a physiological pH of 7.4 with labile coordination sites and facilitates ternary interactions with phosphates and nucleotides. As the pH increased above 9, a spin transition from a high-spin to a low-spin square-planar Ni(II) complex was observed. Employing electrochemical techniques, we showed that interactions between the binary Ni(II)-Aβ complex and phosphate species result in significant changes in the Ni(II) oxidation signal. Thus, the Ni(II)-Aβ complex could potentially serve as a receptor in electrochemical biosensors for phosphate species. The obtained results could also be important for nickel toxicology.

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