Neuroimaging Alterations in Dementia with Lewy Bodies and Neuroimaging Differences Between Dementia with Lewy Bodies and Alzheimer's Disease: An Activation Likelihood Estimation Meta-analysis

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2021 Dec 7

PMID 34873859

Citations 8

Authors

Wen-Ying Ma

Min-Jie Tian

Qun Yao

Qian Li

Fan-Yu Tang

Chao-Yong Xiao

Jing-Ping Shi

Jiu Chen

Affiliations

Soon will be listed here.

Abstract

Aims: The aim of this study was to identify brain regions with local, structural, and functional abnormalities in dementia with Lewy bodies (DLB) and uncover the differences between DLB and Alzheimer's disease (AD). The neural networks involved in the identified abnormal brain regions were further described.

Methods: PubMed, Web of Science, OVID, Science Direct, and Cochrane Library databases were used to identify neuroimaging studies that included DLB versus healthy controls (HCs) or DLB versus AD. The coordinate-based meta-analysis and functional meta-analytic connectivity modeling were performed using the activation likelihood estimation algorithm.

Results: Eleven structural studies and fourteen functional studies were included in this quantitative meta-analysis. DLB patients showed a dysfunction in the bilateral inferior parietal lobule and right lingual gyrus compared with HC patients. DLB patients showed a relative preservation of the medial temporal lobe and a tendency of lower metabolism in the right lingual gyrus compared with AD. The frontal-parietal, salience, and visual networks were all abnormally co-activated in DLB, but the default mode network remained normally co-activated compared with AD.

Conclusions: The convergence of local brain regions and co-activation neural networks might be potential specific imaging markers in the diagnosis of DLB. This might provide a pathway for the neural regulation in DLB patients, and it might contribute to the development of specific interventions for DLB and AD.

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References

Shirer W, Ryali S, Rykhlevskaia E, Menon V, Greicius M . Decoding subject-driven cognitive states with whole-brain connectivity patterns. Cereb Cortex. 2011; 22(1):158-65. PMC: 3236795. DOI: 10.1093/cercor/bhr099. View

Borroni B, Premi E, Formenti A, Turrone R, Alberici A, Cottini E . Structural and functional imaging study in dementia with Lewy bodies and Parkinson's disease dementia. Parkinsonism Relat Disord. 2015; 21(9):1049-55. DOI: 10.1016/j.parkreldis.2015.06.013. View

McKeith I, Boeve B, Dickson D, Halliday G, Taylor J, Weintraub D . Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017; 89(1):88-100. PMC: 5496518. DOI: 10.1212/WNL.0000000000004058. View

Ma W, Yao Q, Hu G, Xiao C, Shi J, Chen J . Dysfunctional Dynamics of Intra- and Inter-network Connectivity in Dementia With Lewy Bodies. Front Neurol. 2019; 10:1265. PMC: 6902076. DOI: 10.3389/fneur.2019.01265. View

Heitz C, Noblet V, Phillipps C, Cretin B, Vogt N, Philippi N . Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer's disease. Alzheimers Res Ther. 2016; 8(1):10. PMC: 4793654. DOI: 10.1186/s13195-016-0179-9. View

Schroeter M, Neumann J . Combined Imaging Markers Dissociate Alzheimer's Disease and Frontotemporal Lobar Degeneration - An ALE Meta-Analysis. Front Aging Neurosci. 2011; 3:10. PMC: 3141339. DOI: 10.3389/fnagi.2011.00010. View

Liguori C, Ruffini R, Olivola E, Chiaravalloti A, Izzi F, Stefani A . Cerebral glucose metabolism in idiopathic REM sleep behavior disorder is different from tau-related and α-synuclein-related neurodegenerative disorders: A brain [18F]FDG PET study. Parkinsonism Relat Disord. 2019; 64:97-105. DOI: 10.1016/j.parkreldis.2019.03.017. View

Montembeault M, Joubert S, Doyon J, Carrier J, Gagnon J, Monchi O . The impact of aging on gray matter structural covariance networks. Neuroimage. 2012; 63(2):754-9. DOI: 10.1016/j.neuroimage.2012.06.052. View

OBrien J, Colloby S, Fenwick J, Williams E, Firbank M, Burn D . Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. Arch Neurol. 2004; 61(6):919-25. DOI: 10.1001/archneur.61.6.919. View

10.

Shimizu S, Hirao K, Kanetaka H, Namioka N, Hatanaka H, Hirose D . Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2015; 43(1):184-192. PMC: 4679785. DOI: 10.1007/s00259-015-3146-y. View

11.

Gomperts S, Locascio J, Marquie M, Santarlasci A, Rentz D, Maye J . Brain amyloid and cognition in Lewy body diseases. Mov Disord. 2012; 27(8):965-73. PMC: 3725259. DOI: 10.1002/mds.25048. View

12.

Muller V, Cieslik E, Laird A, Fox P, Radua J, Mataix-Cols D . Ten simple rules for neuroimaging meta-analysis. Neurosci Biobehav Rev. 2017; 84:151-161. PMC: 5918306. DOI: 10.1016/j.neubiorev.2017.11.012. View

13.

Vidal-Pineiro D, Valls-Pedret C, Fernandez-Cabello S, Arenaza-Urquijo E, Sala-Llonch R, Solana E . Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes. Front Aging Neurosci. 2014; 6:256. PMC: 4174767. DOI: 10.3389/fnagi.2014.00256. View

14.

Schumacher J, Peraza L, Firbank M, Thomas A, Kaiser M, Gallagher P . Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis. Hum Brain Mapp. 2017; 39(3):1118-1129. PMC: 5900719. DOI: 10.1002/hbm.23901. View

15.

Park K, Hong Y, Park J, Park H, Cheon S, Kim J . Pattern of cerebral hypoperfusion according to the clinical staging in dementia with Lewy bodies. Neurocase. 2018; 24(2):83-89. DOI: 10.1080/13554794.2018.1447133. View

16.

Tessitore A, Esposito F, Vitale C, Santangelo G, Amboni M, Russo A . Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease. Neurology. 2012; 79(23):2226-32. DOI: 10.1212/WNL.0b013e31827689d6. View

17.

Ashburner J, Friston K . Voxel-based morphometry--the methods. Neuroimage. 2000; 11(6 Pt 1):805-21. DOI: 10.1006/nimg.2000.0582. View

18.

Murray M, Graff-Radford N, Ross O, Petersen R, Duara R, Dickson D . Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study. Lancet Neurol. 2011; 10(9):785-96. PMC: 3175379. DOI: 10.1016/S1474-4422(11)70156-9. View

19.

Ishii K, Soma T, Kono A, Sofue K, Miyamoto N, Yoshikawa T . Comparison of regional brain volume and glucose metabolism between patients with mild dementia with lewy bodies and those with mild Alzheimer's disease. J Nucl Med. 2007; 48(5):704-11. DOI: 10.2967/jnumed.106.035691. View

20.

Donaghy P, Thomas A, OBrien J . Amyloid PET Imaging in Lewy body disorders. Am J Geriatr Psychiatry. 2013; 23(1):23-37. DOI: 10.1016/j.jagp.2013.03.001. View