Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2021 Dec 6

PMID 34869062

Citations 12

Authors

Xiaoyue Jia

Ran Yang

Jiyao Li

Lei Zhao

Xuedong Zhou

Xin Xu

Affiliations

Soon will be listed here.

Abstract

Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

Citing Articles

Microbiota metabolites in bone: Shaping health and Confronting disease.

Han D, Wang W, Gong J, Ma Y, Li Y Heliyon. 2024; 10(7):e28435.

PMID: 38560225 PMC: 10979239. DOI: 10.1016/j.heliyon.2024.e28435.

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis.

Wu J, Yao L, Liu Y, Zhang S, Wang K Braz J Med Biol Res. 2024; 57:e12951.

PMID: 38511766 PMC: 10946243. DOI: 10.1590/1414-431X2024e12951.

Potential effects of specific gut microbiota on periodontal disease: a two-sample bidirectional Mendelian randomization study.

Xu M, Shao Q, Zhou Y, Yu Y, Wang S, Wang A Front Microbiol. 2024; 15:1322947.

PMID: 38314435 PMC: 10834673. DOI: 10.3389/fmicb.2024.1322947.

The association between plain water intake and periodontitis in the population aged over 45: a cross-sectional study based on NHANES 2009-2014.

Li X, Wang L, Yang L, Liu X, Liu H, Mu Y BMC Oral Health. 2024; 24(1):27.

PMID: 38183113 PMC: 10770954. DOI: 10.1186/s12903-023-03809-y.

Gut-Brain Crosstalk and the Central Mechanisms of Orofacial Pain.

Tao R, Liu S, Crawford J, Tao F Brain Sci. 2023; 13(10).

PMID: 37891825 PMC: 10605055. DOI: 10.3390/brainsci13101456.

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