Pitfalls in the Diagnosis of Yolk Sac Tumor: Lessons from a Clinical Trial

Overview

Journal Pediatr Blood Cancer

Specialties Hematology
Oncology
Pediatrics

Date 2021 Dec 6

PMID 34866303

Citations 1

Authors

Adeline Yang

Alison Patterson

Tara Pavlock

Kenneth S Chen

Jeffrey Gagan

Mark E Hatley

A Lindsay Frazier

James F Amatruda

Theodore W Laetsch

Dinesh Rakheja

Affiliations

Soon will be listed here.

Abstract

Though outcomes for patients with recurrent/refractory malignant germ cell tumors (mGCTs) are poor, therapies targeting mTOR and EGFR inhibition have shown promise in vitro. We hypothesized that the combination of sirolimus and erlotinib will show activity in patients with recurrent/refractory mGCTs. Patients were enrolled in a prospective phase II clinical trial; central review of existing pathology specimens was performed. Of the five patients evaluated, two had their diagnoses revised to pancreatic acinar cell carcinoma and alpha-fetoprotein (AFP)-secreting gastric adenocarcinoma, respectively. Although mGCTs are common AFP-secreting neoplasms, recurrence or refractoriness to standard regimens should prompt histologic reevaluation for other diagnoses.

Citing Articles

Role of Alpha-Fetoprotein (AFP) in Diagnosing Childhood Cancers and Genetic-Related Chronic Diseases.

Glowska-Ciemny J, Szymanski M, Kuszerska A, Rzepka R, von Kaisenberg C, Kocylowski R Cancers (Basel). 2023; 15(17).

PMID: 37686577 PMC: 10486785. DOI: 10.3390/cancers15174302.

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