Cellulose-Based Nanofibril Composite Materials As a New Approach to Fight Bacterial Infections

Overview

Journal Front Bioeng Biotechnol

Date 2021 Dec 3

PMID 34858953

Citations 2

Authors

Somaye Rashki

Neda Shakour

Zahra Yousefi

Marzieh Rezaei

Mina Homayoonfal

Ehsan Khabazian

Fatemeh Atyabi

Fatemeh Aslanbeigi

Rouzita Safaei Lapavandani

Samaneh Mazaheri

Michael R Hamblin

Hamed Mirzaei

Affiliations

Soon will be listed here.

Abstract

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections.

Citing Articles

A Comprehensive Review on Cellulose Nanofibers, Nanomaterials, and Composites: Manufacturing, Properties, and Applications.

Antony Jose S, Cowan N, Davidson M, Godina G, Smith I, Xin J Nanomaterials (Basel). 2025; 15(5).

PMID: 40072159 PMC: 11901645. DOI: 10.3390/nano15050356.

Life-Cycle Risk Assessment of Second-Generation Cellulose Nanomaterials.

Ede J, Charlton-Sevcik A, Griffin J, Srinivasan P, Zhang Y, Sayes C Nanomaterials (Basel). 2025; 15(3).

PMID: 39940214 PMC: 11819754. DOI: 10.3390/nano15030238.

Antimicrobial Activity of Amino-Modified Cellulose Nanofibrils Decorated with Silver Nanoparticles.

Lazic V, Nedeljkovic J, Kokol V J Funct Biomater. 2024; 15(10).

PMID: 39452602 PMC: 11508708. DOI: 10.3390/jfb15100304.

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections.

Alipoor R, Ayan M, Hamblin M, Ranjbar R, Rashki S Front Bioeng Biotechnol. 2022; 10:913912.

PMID: 35757807 PMC: 9213665. DOI: 10.3389/fbioe.2022.913912.

References

Halawany H . A review on miswak (Salvadora persica) and its effect on various aspects of oral health. Saudi Dent J. 2013; 24(2):63-9. PMC: 3723367. DOI: 10.1016/j.sdentj.2011.12.004. View

Abe K, Iwamoto S, Yano H . Obtaining cellulose nanofibers with a uniform width of 15 nm from wood. Biomacromolecules. 2007; 8(10):3276-8. DOI: 10.1021/bm700624p. View

Wang L, Hu C, Shao L . The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine. 2017; 12:1227-1249. PMC: 5317269. DOI: 10.2147/IJN.S121956. View

Oun A, Rhim J . Preparation of multifunctional chitin nanowhiskers/ZnO-Ag NPs and their effect on the properties of carboxymethyl cellulose-based nanocomposite film. Carbohydr Polym. 2017; 169:467-479. DOI: 10.1016/j.carbpol.2017.04.042. View

Singla R, Soni S, Patial V, Kulurkar P, Kumari A, S M . Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing. Sci Rep. 2017; 7(1):10457. PMC: 5585312. DOI: 10.1038/s41598-017-08897-9. View

Sulaiman S, Mokhtar M, Naim M, Baharuddin A, Sulaiman A . A review: potential usage of cellulose nanofibers (CNF) for enzyme immobilization via covalent interactions. Appl Biochem Biotechnol. 2014; 175(4):1817-42. DOI: 10.1007/s12010-014-1417-x. View

Gupta K, Singh R, Pandey A, Pandey A . Photocatalytic antibacterial performance of TiO2 and Ag-doped TiO2 against S. aureus. P. aeruginosa and E. coli. Beilstein J Nanotechnol. 2013; 4:345-51. PMC: 3701421. DOI: 10.3762/bjnano.4.40. View

Kong M, Chen X, Xing K, Park H . Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010; 144(1):51-63. DOI: 10.1016/j.ijfoodmicro.2010.09.012. View

Jatoi A, Jo Y, Lee H, Oh S, Hwang D, Khatri Z . Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver-anchored silica nanoparticles. J Biomed Mater Res B Appl Biomater. 2017; 106(3):1121-1128. DOI: 10.1002/jbm.b.33925. View

10.

Tavakolian M, Okshevsky M, van de Ven T, Tufenkji N . Developing Antibacterial Nanocrystalline Cellulose Using Natural Antibacterial Agents. ACS Appl Mater Interfaces. 2018; 10(40):33827-33838. DOI: 10.1021/acsami.8b08770. View

11.

Balakrishnan B, Mohanty M, Umashankar P, Jayakrishnan A . Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials. 2005; 26(32):6335-42. DOI: 10.1016/j.biomaterials.2005.04.012. View

12.

Poonguzhali R, Basha S, Kumari V . Synthesis and characterization of chitosan-PVP-nanocellulose composites for in-vitro wound dressing application. Int J Biol Macromol. 2017; 105(Pt 1):111-120. DOI: 10.1016/j.ijbiomac.2017.07.006. View

13.

Ghanbari Mehrabani M, Karimian R, Mehramouz B, Rahimi M, Kafil H . Preparation of biocompatible and biodegradable silk fibroin/chitin/silver nanoparticles 3D scaffolds as a bandage for antimicrobial wound dressing. Int J Biol Macromol. 2018; 114:961-971. DOI: 10.1016/j.ijbiomac.2018.03.128. View

14.

Ghanbari Mehrabani M, Karimian R, Rakhshaei R, Pakdel F, Eslami H, Fakhrzadeh V . Chitin/silk fibroin/TiO bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity. Int J Biol Macromol. 2018; 116:966-976. DOI: 10.1016/j.ijbiomac.2018.05.102. View

15.

Sampaio L, Padrao J, Faria J, Silva J, Silva C, Dourado F . Laccase immobilization on bacterial nanocellulose membranes: Antimicrobial, kinetic and stability properties. Carbohydr Polym. 2016; 145:1-12. DOI: 10.1016/j.carbpol.2016.03.009. View

16.

Missoum K, Belgacem M, Bras J . Nanofibrillated Cellulose Surface Modification: A Review. Materials (Basel). 2017; 6(5):1745-1766. PMC: 5452503. DOI: 10.3390/ma6051745. View

17.

Galkina O, Onneby K, Huang P, Ivanov V, Agafonov A, Seisenbaeva G . Antibacterial and photochemical properties of cellulose nanofiber-titania nanocomposites loaded with two different types of antibiotic medicines. J Mater Chem B. 2020; 3(35):7125-7134. DOI: 10.1039/c5tb01382h. View

18.

Lan G, Lu B, Wang T, Wang L, Chen J, Yu K . Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent. Colloids Surf B Biointerfaces. 2015; 136:1026-34. DOI: 10.1016/j.colsurfb.2015.10.039. View

19.

Lavoine N, Desloges I, Dufresne A, Bras J . Microfibrillated cellulose - its barrier properties and applications in cellulosic materials: a review. Carbohydr Polym. 2012; 90(2):735-64. DOI: 10.1016/j.carbpol.2012.05.026. View

20.

Liga M, Bryant E, Colvin V, Li Q . Virus inactivation by silver doped titanium dioxide nanoparticles for drinking water treatment. Water Res. 2010; 45(2):535-44. DOI: 10.1016/j.watres.2010.09.012. View