Biomaterials-based Approaches for Cardiac Regeneration

Overview

Journal Korean Circ J

Date 2021 Dec 2

PMID 34854577

Citations 11

Authors

Samhita Vasu

Justin Zhou

Jeffrey Chen

Peter V Johnston

Deok-Ho Kim

Affiliations

Soon will be listed here.

Abstract

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.

Citing Articles

Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments.

Holme S, Richardson S, Bella J, Pinali C Int J Mol Sci. 2025; 26(5).

PMID: 40076929 PMC: 11900105. DOI: 10.3390/ijms26052309.

Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy.

An C, Zhao Y, Guo L, Zhang Z, Yan C, Zhang S Mater Today Bio. 2025; 31:101476.

PMID: 39896290 PMC: 11787032. DOI: 10.1016/j.mtbio.2025.101476.

The future of cardiac repair: a review on cell-free nanotherapies for regenerative myocardial infarction.

Kamal N, A Heikal L, Abdallah O Drug Deliv Transl Res. 2025; .

PMID: 39833466 DOI: 10.1007/s13346-024-01763-y.

Use of Hydrogels in Regenerative Medicine: Focus on Mechanical Properties.

Carton F, Rizzi M, Canciani E, Sieve G, Di Francesco D, Casarella S Int J Mol Sci. 2024; 25(21).

PMID: 39518979 PMC: 11545898. DOI: 10.3390/ijms252111426.

Engineering extracellular vesicles for ROS scavenging and tissue regeneration.

Abdal Dayem A, Yan E, Do M, Kim Y, Lee Y, Cho S Nano Converg. 2024; 11(1):24.

PMID: 38922501 PMC: 11208369. DOI: 10.1186/s40580-024-00430-9.

References

Gao L, Kupfer M, Jung J, Yang L, Zhang P, Sie Y . Myocardial Tissue Engineering With Cells Derived From Human-Induced Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold. Circ Res. 2017; 120(8):1318-1325. PMC: 5392171. DOI: 10.1161/CIRCRESAHA.116.310277. View

Shin Y, Shafranek R, Tsui J, Walcott J, Nelson A, Kim D . 3D bioprinting of mechanically tuned bioinks derived from cardiac decellularized extracellular matrix. Acta Biomater. 2020; 119:75-88. DOI: 10.1016/j.actbio.2020.11.006. View

Pena B, Laughter M, Jett S, Rowland T, Taylor M, Mestroni L . Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci. 2018; 18(6):e1800079. PMC: 6166441. DOI: 10.1002/mabi.201800079. View

Spadaccio C, Nappi F, De Marco F, Sedati P, Taffon C, Nenna A . Implantation of a Poly-L-Lactide GCSF-Functionalized Scaffold in a Model of Chronic Myocardial Infarction. J Cardiovasc Transl Res. 2017; 10(1):47-65. PMC: 5323505. DOI: 10.1007/s12265-016-9718-9. View

Rao S, Zeymer U, Douglas P, Al-Khalidi H, White J, Liu J . Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction. J Am Coll Cardiol. 2016; 68(7):715-23. DOI: 10.1016/j.jacc.2016.05.053. View

Hasan A, Khattab A, Islam M, Hweij K, Zeitouny J, Waters R . Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction. Adv Sci (Weinh). 2016; 2(11):1500122. PMC: 5033116. DOI: 10.1002/advs.201500122. View

Deng C, Zhang P, Vulesevic B, Kuraitis D, Li F, Yang A . A collagen–chitosan hydrogel for endothelial differentiation and angiogenesis. Tissue Eng Part A. 2010; 16(10):3099-109. DOI: 10.1089/ten.tea.2009.0504. View

Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, Lou X . Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine. Circulation. 2017; 137(16):1712-1730. PMC: 5903991. DOI: 10.1161/CIRCULATIONAHA.117.030785. View

Carson D, Hnilova M, Yang X, Nemeth C, Tsui J, Smith A . Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells. ACS Appl Mater Interfaces. 2016; 8(34):21923-32. PMC: 5681855. DOI: 10.1021/acsami.5b11671. View

10.

Kim D, Kshitiz , Smith R, Kim P, Ahn E, Kim H . Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb). 2012; 4(9):1019-33. DOI: 10.1039/c2ib20067h. View

11.

Smith A, Yoo H, Yi H, Ahn E, Lee J, Shao G . Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering. Chem Commun (Camb). 2017; 53(53):7412-7415. PMC: 5548490. DOI: 10.1039/c7cc01988b. View

12.

Ravichandran R, Venugopal J, Mukherjee S, Sundarrajan S, Ramakrishna S . Elastomeric core/shell nanofibrous cardiac patch as a biomimetic support for infarcted porcine myocardium. Tissue Eng Part A. 2015; 21(7-8):1288-98. DOI: 10.1089/ten.TEA.2014.0265. View

13.

Mehrotra S, de Melo B, Hirano M, Keung W, Li R, Mandal B . Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium-on-a-Chip Application. Adv Funct Mater. 2020; 30(12). PMC: 7566555. DOI: 10.1002/adfm.201907436. View

14.

Macadangdang J, Lee H, Carson D, Jiao A, Fugate J, Pabon L . Capillary force lithography for cardiac tissue engineering. J Vis Exp. 2014; (88). PMC: 4188383. DOI: 10.3791/50039. View

15.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X . Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials. 2016; 105:52-65. DOI: 10.1016/j.biomaterials.2016.07.035. View

16.

Pok S, Benavides O, Hallal P, Jacot J . Use of myocardial matrix in a chitosan-based full-thickness heart patch. Tissue Eng Part A. 2014; 20(13-14):1877-87. PMC: 4086522. DOI: 10.1089/ten.TEA.2013.0620. View

17.

Wang Q, Wang H, Li Z, Wang Y, Wu X, Tan Y . Mesenchymal stem cell-loaded cardiac patch promotes epicardial activation and repair of the infarcted myocardium. J Cell Mol Med. 2017; 21(9):1751-1766. PMC: 5571540. DOI: 10.1111/jcmm.13097. View

18.

Cristallini C, Vaccari G, Barbani N, Cibrario Rocchietti E, Barberis R, Falzone M . Cardioprotection of PLGA/gelatine cardiac patches functionalised with adenosine in a large animal model of ischaemia and reperfusion injury: A feasibility study. J Tissue Eng Regen Med. 2019; 13(7):1253-1264. PMC: 6771506. DOI: 10.1002/term.2875. View

19.

Chaterji S, Ahn E, Kim D . CRISPR Genome Engineering for Human Pluripotent Stem Cell Research. Theranostics. 2017; 7(18):4445-4469. PMC: 5695142. DOI: 10.7150/thno.18456. View

20.

Williams N, Rhodehamel M, Yan C, Smith A, Jiao A, Murry C . Engineering anisotropic 3D tubular tissues with flexible thermoresponsive nanofabricated substrates. Biomaterials. 2020; 240:119856. PMC: 7536133. DOI: 10.1016/j.biomaterials.2020.119856. View