Injectable Hydrogels for Cardiac Tissue Engineering

Overview

Journal Macromol Biosci

Specialties Biochemistry
Biology

Date 2018 May 8

PMID 29733514

Citations 74

Authors

Brisa Pena

Melissa Laughter

Susan Jett

Teisha J Rowland

Matthew R G Taylor

Luisa Mestroni

Daewon Park

Affiliations

Soon will be listed here.

Abstract

In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF). This review provides an overview of recent developments that have occurred in the design and engineering of various injectable hydrogel systems for cardiac tissue engineering efforts, including a comparison of natural versus synthetic systems with emphasis on the ideal characteristics for biomimetic cardiac materials.

Citing Articles

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