Local Antibiotic Delivery Systems in Diabetic Foot Osteomyelitis: A Brief Review

Overview

Journal Rev Diabet Stud

Specialty Endocrinology

Date 2021 Dec 2

PMID 34852898

Citations 1

Authors

Christos Chatzipapas

Makrina Karaglani

Nikolaos Papanas

Konstantinos Tilkeridis

Georgios I Drosos

Affiliations

Soon will be listed here.

Abstract

Diabetic foot osteomyelitis (DFO) is a severe, difficult to treat infection. Local antibiotic delivery has been studied as a potential therapeutic adjunct following surgery for DFO. This review aims to summarize the evidence on local antibiotic delivery systems in DFO. PubMed database was searched up to March 2020. Overall, 16 studies were identified and included: 3 randomized controlled trials (RCTs), 3 retrospective studies (RSs), and 10 case series. In the RCTs, gentamicin-impregnated collagen sponges significantly improved clinical healing rates and slightly improved duration of hospitalization. In the RSs, antibiotic-impregnated calcium sulfate beads non-significantly improved all healing parameters, but did not reduce post-operative amputation rates or time of healing. The majority of case series used calcium sulfate beads, achieving adequate rates of healing and eradication of infection. In conclusion, evidence for add-on local antibiotic delivery in DFO is still limited; more data are needed to assess this therapeutic measure.

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PMID: 36862164 PMC: 10079742. DOI: 10.1007/s00264-023-05727-8.

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