Gentamycin Elution from Polymethylmethacrylate and Bone Graft Substitute: Comparison Between Commercially Available and Home-made Preparations

Overview

Journal J Orthop

Specialty Orthopedics

Date 2020 Feb 6

PMID 32021027

Citations 5

Authors

Makrina Karaglani

Evmorfia Tzitzikou

Stylianos Tottas

Ioannis Kougioumtzis

Konstantinos Arvanitidis

George Kolios

Ekaterini Chatzaki

Georgios I Drosos

Affiliations

Soon will be listed here.

Abstract

Polymethylmethacrylate (PMMA) represents the current gold standard as an antibiotic delivery carrier in orthopaedic surgery. Despite the accepted use of local antibiotic carriers, there aren't any conclusive data comparing PMMA to Bone Graft Substitutes. The aim of this study was to compare the elution profile of gentamicin from various preparations of PMMA cements and Herafill beads. All cements had high initial elution during the first hour which then slowly decreased, Herafill beads on the other hand showed its higher elution around the eighth hour. Herafill, in general, presented the highest elution of gentamicin regardless of its input amount.

Citing Articles

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Effect of the Antimicrobial Agents Peppermint Essential Oil and Silver Nanoparticles on Bone Cement Properties.

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Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties.

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Prophylactic Antibiofilm Activity of Antibiotic-Loaded Bone Cements against Gram-Negative Bacteria.

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Local Antibiotic Delivery Systems in Diabetic Foot Osteomyelitis: A Brief Review.

Chatzipapas C, Karaglani M, Papanas N, Tilkeridis K, Drosos G Rev Diabet Stud. 2021; 17(2):75-81.

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