Anticancer Potential of L-Histidine-Capped Silver Nanoparticles Against Human Cervical Cancer Cells (SiHA)

Overview

Journal Nanomaterials (Basel)

Date 2021 Nov 27

PMID 34835918

Citations 4

Authors

Rajmohamed Mohammed Asik

Chidhambaram Manikkaraja

Karuppusamy Tamil Surya

Natarajan Suganthy

Archunan Priya Aarthy

Domokos Mathe

Muthusamy Sivakumar

Govindaraju Archunan

Parasuraman Padmanabhan

Balazs Gulyas

Affiliations

Soon will be listed here.

Abstract

This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of -20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.

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References

Qayyum S, Oves M, Khan A . Obliteration of bacterial growth and biofilm through ROS generation by facilely synthesized green silver nanoparticles. PLoS One. 2017; 12(8):e0181363. PMC: 5542591. DOI: 10.1371/journal.pone.0181363. View

Tang Z, Liu Y, He M, Bu W . Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions. Angew Chem Int Ed Engl. 2018; 58(4):946-956. DOI: 10.1002/anie.201805664. View

Foroozandeh P, Abdul Aziz A . Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles. Nanoscale Res Lett. 2018; 13(1):339. PMC: 6202307. DOI: 10.1186/s11671-018-2728-6. View

Huy T, Huyen P, Le A, Tonezzer M . Recent Advances of Silver Nanoparticles in Cancer Diagnosis and Treatment. Anticancer Agents Med Chem. 2019; 20(11):1276-1287. DOI: 10.2174/1871520619666190710121727. View

Mosmann T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2):55-63. DOI: 10.1016/0022-1759(83)90303-4. View

Nivedhini Iswarya C, Kiruba Daniel S, Sivakumar M . Studies on l-histidine capped Ag and Au nanoparticles for dopamine detection. Mater Sci Eng C Mater Biol Appl. 2017; 75:393-401. DOI: 10.1016/j.msec.2016.11.102. View

Ratan Z, Haidere M, Nurunnabi M, Shahriar S, Saleh Ahammad A, Shim Y . Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects. Cancers (Basel). 2020; 12(4). PMC: 7226404. DOI: 10.3390/cancers12040855. View

Yaqoob A, Ahmad H, Parveen T, Ahmad A, Oves M, Ismail I . Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review. Front Chem. 2020; 8:341. PMC: 7248377. DOI: 10.3389/fchem.2020.00341. View

Shankar S, Rhim J . Amino acid mediated synthesis of silver nanoparticles and preparation of antimicrobial agar/silver nanoparticles composite films. Carbohydr Polym. 2015; 130:353-63. DOI: 10.1016/j.carbpol.2015.05.018. View

10.

Kulandaisamy A, Rayappan J . Significance of Nanoparticles and the Role of Amino Acids in Structuring Them-A Review. J Nanosci Nanotechnol. 2018; 18(8):5222-5233. DOI: 10.1166/jnn.2018.15388. View

11.

Yuan Y, Zhang S, Hwang J, Kong I . Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells. Oxid Med Cell Longev. 2019; 2018:6121328. PMC: 6311846. DOI: 10.1155/2018/6121328. View

12.

Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A . Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics. 2018; 10(2). PMC: 6027495. DOI: 10.3390/pharmaceutics10020057. View

13.

Daduang J, Palasap A, Daduang S, Boonsiri P, Suwannalert P, Limpaiboon T . Gallic acid enhancement of gold nanoparticle anticancer activity in cervical cancer cells. Asian Pac J Cancer Prev. 2015; 16(1):169-74. DOI: 10.7314/apjcp.2015.16.1.169. View

14.

Liu Z, Zu Y, Fu Y, Meng R, Guo S, Xing Z . Hydrothermal synthesis of histidine-functionalized single-crystalline gold nanoparticles and their pH-dependent UV absorption characteristic. Colloids Surf B Biointerfaces. 2009; 76(1):311-6. DOI: 10.1016/j.colsurfb.2009.11.010. View

15.

Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G . ROS in cancer therapy: the bright side of the moon. Exp Mol Med. 2020; 52(2):192-203. PMC: 7062874. DOI: 10.1038/s12276-020-0384-2. View

16.

Hai X, Zhu X, Yu K, Yue S, Song W, Bi S . Dual-mode glucose nanosensor as an activatable theranostic platform for cancer cell recognition and cascades-enhanced synergetic therapy. Biosens Bioelectron. 2021; 192:113544. DOI: 10.1016/j.bios.2021.113544. View

17.

Al-Sheddi E, Farshori N, Al-Oqail M, Al-Massarani S, Saquib Q, Wahab R . Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of against Human Cervical Cancer Cells (HeLA). Bioinorg Chem Appl. 2018; 2018:9390784. PMC: 6236914. DOI: 10.1155/2018/9390784. View

18.

Iravani S, Korbekandi H, Mirmohammadi S, Zolfaghari B . Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci. 2015; 9(6):385-406. PMC: 4326978. View

19.

Roesslein M, Hirsch C, Kaiser J, Krug H, Wick P . Comparability of in vitro tests for bioactive nanoparticles: a common assay to detect reactive oxygen species as an example. Int J Mol Sci. 2013; 14(12):24320-37. PMC: 3876113. DOI: 10.3390/ijms141224320. View

20.

Zhang C, Wang X, Du J, Gu Z, Zhao Y . Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment. Adv Sci (Weinh). 2021; 8(3):2002797. PMC: 7856897. DOI: 10.1002/advs.202002797. View