(Nano)biotechnological Approaches in the Treatment of Cervical Cancer: Integration of Engineering and Biology

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Sep 30

PMID 39346915

Authors

Weimin Xie

Zhengmei Xu

Affiliations

Soon will be listed here.

Abstract

Cervical cancer is one of the most malignant gynaecological tumors characterised with the aggressive behaviour of the tumor cells. In spite of the development of different strategies for the treatment of cervical cancer, the tumor cells have developed resistance to conventional therapeutics. On the other hand, nanoparticles have been recently applied for the treatment of human cancers through delivery of drugs and facilitate tumor suppression. The stimuli-sensitive nanostructures can improve the release of therapeutics at the tumor site. In the present review, the nanostructures for the treatment of cervical cancer are discussed. Nanostructures can deliver both chemotherapy drugs and natural compounds to increase anti-cancer activity and prevent drug resistance in cervical tumor. Moreover, the genetic tools such as siRNA can be delivered by nanoparticles to enhance their accumulation at tumor site. In order to enhance selectivity, the stimuli-responsive nanoparticles such as pH- and redox-responsive nanocarriers have been developed to suppress cervical tumor. Moreover, nanoparticles can induce photo-thermal and photodynamic therapy to accelerate cell death in cervical tumor. In addition, nanobiotechnology demonstrates tremendous potential in the treatment of cervical cancer, especially in the context of tumor immunotherapy. Overall, metal-, carbon-, lipid- and polymer-based nanostructures have been utilized in cervical cancer therapy. Finally, hydrogels have been developed as novel kinds of carriers to encapsulate therapeutics and improve anti-cancer activity.

References

de Jong W, Borm P . Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008; 3(2):133-49. PMC: 2527668. DOI: 10.2147/ijn.s596. View

Wang X, Wang J, Wu W, Li H . Vaginal delivery of carboplatin-loaded thermosensitive hydrogel to prevent local cervical cancer recurrence in mice. Drug Deliv. 2016; 23(9):3544-3551. DOI: 10.1080/10717544.2016.1205158. View

Yadav R, Das P, Sharma S, SenGupta S, Kumar D, Sagar R . Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment. Med Oncol. 2023; 40(12):347. DOI: 10.1007/s12032-023-02195-3. View

Yu H, Zheng R, Lei F, Wang W, Guo W, Zhang L . Antibody-conjugated silica-coated gold nanoparticles in targeted therapy of cervical cancer. Am J Transl Res. 2022; 14(3):1518-1534. PMC: 8991142. View

Li Z, Fan J, Tong C, Zhou H, Wang W, Li B . A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy. Nanomedicine (Lond). 2019; 14(15):2011-2025. DOI: 10.2217/nnm-2018-0378. View

Lisik K, Krokosz A . Application of Carbon Nanoparticles in Oncology and Regenerative Medicine. Int J Mol Sci. 2021; 22(15). PMC: 8347552. DOI: 10.3390/ijms22158341. View

Luo W . Predicting Cervical Cancer Outcomes: Statistics, Images, and Machine Learning. Front Artif Intell. 2021; 4:627369. PMC: 8215338. DOI: 10.3389/frai.2021.627369. View

Furukawa N, Popel A . Peptides that immunoactivate the tumor microenvironment. Biochim Biophys Acta Rev Cancer. 2020; 1875(1):188486. PMC: 8369429. DOI: 10.1016/j.bbcan.2020.188486. View

Panyam J, Labhasetwar V . Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev. 2003; 55(3):329-47. DOI: 10.1016/s0169-409x(02)00228-4. View

10.

Karan D, Dubey S, Pirisi L, Nagel A, Pina I, Choo Y . The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein. J Nat Prod. 2020; 83(2):286-295. PMC: 7161578. DOI: 10.1021/acs.jnatprod.9b00577. View

11.

Aggarwal U, Goyal A, Rath G . Development of Drug Targeting and Delivery in Cervical Cancer. Curr Cancer Drug Targets. 2017; 18(8):792-806. DOI: 10.2174/1568009617666171009165105. View

12.

Vasanthakumar A, Rejeeth C, Vivek R, Ponraj T, Jayaraman K, Anandasadagopan S . Design of Bio-Graphene-Based Multifunctional Nanocomposites Exhibits Intracellular Drug Delivery in Cervical Cancer Treatment. ACS Appl Bio Mater. 2022; 5(6):2956-2964. DOI: 10.1021/acsabm.2c00280. View

13.

Song Y, Wang S . Melatonin synergistically enhances docetaxel induced endoplasmic reticulum stress to promote apoptosis by suppressing NF-κB activation in cervical cancer. Med Oncol. 2023; 40(8):219. DOI: 10.1007/s12032-023-02087-6. View

14.

Veiseh O, Gunn J, Zhang M . Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2009; 62(3):284-304. PMC: 2827645. DOI: 10.1016/j.addr.2009.11.002. View

15.

Lee K, Baek S, Yoon M, Park J, Hong B, Lee S . Potential anticancer effect of aspirin and 2'-hydroxy-2,3,5'-trimethoxychalcone-linked polymeric micelles against cervical cancer through apoptosis. Oncol Lett. 2021; 23(1):31. PMC: 8669688. DOI: 10.3892/ol.2021.13149. View

16.

Vaghasia H, Sakaria S, Prajapati J, Saraf M, Rawal R . Interactive bioinformatics analysis for the screening of hub genes and molecular docking of phytochemicals present in kitchen spices to inhibit CDK1 in cervical cancer. Comput Biol Med. 2022; 149:105994. DOI: 10.1016/j.compbiomed.2022.105994. View

17.

Zhang M, Liu X, Mao Y, He Y, Xu J, Zheng F . Oxygen-Generating Hydrogels Overcome Tumor Hypoxia to Enhance Photodynamic/Gas Synergistic Therapy. ACS Appl Mater Interfaces. 2022; 14(24):27551-27563. DOI: 10.1021/acsami.2c02949. View

18.

Tan X, Wang X, Liao X, Wang X, Jiang Z, Liang W . Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1. iScience. 2023; 26(8):107315. PMC: 10372835. DOI: 10.1016/j.isci.2023.107315. View

19.

Zhang S, Xu H, Zhang L, Qiao Y . Cervical cancer: Epidemiology, risk factors and screening. Chin J Cancer Res. 2021; 32(6):720-728. PMC: 7797226. DOI: 10.21147/j.issn.1000-9604.2020.06.05. View

20.

Vega D, Lodge P, Vivero-Escoto J . Redox-Responsive Porphyrin-Based Polysilsesquioxane Nanoparticles for Photodynamic Therapy of Cancer Cells. Int J Mol Sci. 2016; 17(1). PMC: 4730301. DOI: 10.3390/ijms17010056. View