Gastric Microbiota Beyond : An Emerging Critical Character in Gastric Carcinogenesis

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Nov 27

PMID 34829909

Citations 12

Authors

Jun Wen

Harry Cheuk-Hay Lau

Maikel Peppelenbosch

Jun Yu

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) is one of the global leading causes of cancer death. The association between , which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non- gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.

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