Current Insights into Atopic March

Overview

Journal Children (Basel)

Specialty Health Services

Date 2021 Nov 27

PMID 34828780

Citations 30

Authors

Mitsuru Tsuge

Masanori Ikeda

Naomi Matsumoto

Takashi Yorifuji

Hirokazu Tsukahara

Affiliations

Soon will be listed here.

Abstract

The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as "atopic march". Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset.

Citing Articles

Connecting electronic health records to a biomedical knowledge graph to link clinical phenotypes and molecular endotypes in atopic dermatitis.

Frau F, Loustalot P, Tornqvist M, Temam N, Cupe J, Montmerle M Sci Rep. 2025; 15(1):3082.

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Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis.

Kwon B, Kim D, Shim K, Nguyen C, Lee H, Kang D Dermatol Res Pract. 2025; 2025():2376970.

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Atopic Dermatitis: A Review of Diagnosis and Treatment.

Jeskey J, Kurien C, Blunk H, Sehmi K, Areti S, Nguyen D J Pediatr Pharmacol Ther. 2024; 29(6):587-603.

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Reducing disparities in the care of atopic dermatitis.

Nwaneri U, Heath C, Alexis A, Friedman A, Silverberg J Arch Dermatol Res. 2024; 316(10):688.

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V Brazilian Consensus on Rhinitis - 2024.

Sole D, Kuschnir F, Pastorino A, Constantino C, Galvao C, Chong E Silva D Braz J Otorhinolaryngol. 2024; 91(1):101500.

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References

Jesenak M, Zelieskova M, Babusikova E . Oxidative Stress and Bronchial Asthma in Children-Causes or Consequences?. Front Pediatr. 2017; 5:162. PMC: 5523023. DOI: 10.3389/fped.2017.00162. View

Brozek J, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S . Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017; 140(4):950-958. DOI: 10.1016/j.jaci.2017.03.050. View

Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A . Increased oxidative stress in childhood atopic dermatitis. Life Sci. 2001; 69(2):223-8. DOI: 10.1016/s0024-3205(01)01124-9. View

Bertino L, Guarneri F, Cannavo S, Casciaro M, Pioggia G, Gangemi S . Oxidative Stress and Atopic Dermatitis. Antioxidants (Basel). 2020; 9(3). PMC: 7139929. DOI: 10.3390/antiox9030196. View

Du Toit G, Sayre P, Roberts G, Sever M, Lawson K, Bahnson H . Effect of Avoidance on Peanut Allergy after Early Peanut Consumption. N Engl J Med. 2016; 374(15):1435-43. DOI: 10.1056/NEJMoa1514209. View

Katz Y, Rajuan N, Goldberg M, Eisenberg E, Heyman E, Cohen A . Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J Allergy Clin Immunol. 2010; 126(1):77-82.e1. DOI: 10.1016/j.jaci.2010.04.020. View

Ker J, Hartert T . The atopic march: what's the evidence?. Ann Allergy Asthma Immunol. 2009; 103(4):282-9. PMC: 4686261. DOI: 10.1016/S1081-1206(10)60526-1. View

Ierodiakonou D, Garcia-Larsen V, Logan A, Groome A, Cunha S, Chivinge J . Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis. JAMA. 2016; 316(11):1181-1192. DOI: 10.1001/jama.2016.12623. View

Kusel M, de Klerk N, Kebadze T, Vohma V, Holt P, Johnston S . Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007; 119(5):1105-10. PMC: 7125611. DOI: 10.1016/j.jaci.2006.12.669. View

10.

Hill D, Spergel J . The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol. 2018; 120(2):131-137. PMC: 5806141. DOI: 10.1016/j.anai.2017.10.037. View

11.

Han H, Roan F, Ziegler S . The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol Rev. 2017; 278(1):116-130. PMC: 5492959. DOI: 10.1111/imr.12546. View

12.

Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari M, Di Mauro A . Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis. Allergy. 2015; 70(11):1356-71. DOI: 10.1111/all.12700. View

13.

Snijders B, Thijs C, van Ree R, van den Brandt P . Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics. 2008; 122(1):e115-22. DOI: 10.1542/peds.2007-1651. View

14.

Hammad H, Lambrecht B . Barrier Epithelial Cells and the Control of Type 2 Immunity. Immunity. 2015; 43(1):29-40. DOI: 10.1016/j.immuni.2015.07.007. View

15.

Lowe A, Su J, Tang M, Lodge C, Matheson M, Allen K . PEBBLES study protocol: a randomised controlled trial to prevent atopic dermatitis, food allergy and sensitisation in infants with a family history of allergic disease using a skin barrier improvement strategy. BMJ Open. 2019; 9(3):e024594. PMC: 6430027. DOI: 10.1136/bmjopen-2018-024594. View

16.

Du Toit G, Roberts G, Sayre P, Plaut M, Bahnson H, Mitchell H . Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study. J Allergy Clin Immunol. 2012; 131(1):135-43.e1-12. DOI: 10.1016/j.jaci.2012.09.015. View

17.

Tan J, Valerio C, Barnes E, Turner P, Van Asperen P, Kakakios A . A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J Allergy Clin Immunol. 2016; 139(5):1621-1628.e8. DOI: 10.1016/j.jaci.2016.08.035. View

18.

Boyle R, Ierodiakonou D, Khan T, Chivinge J, Robinson Z, Geoghegan N . Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis. BMJ. 2016; 352:i974. PMC: 4783517. DOI: 10.1136/bmj.i974. View

19.

Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M . Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol. 2004; 113(1):86-93. DOI: 10.1016/j.jaci.2003.10.010. View

20.

Koplin J, Osborne N, Wake M, Martin P, Gurrin L, Robinson M . Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol. 2010; 126(4):807-13. DOI: 10.1016/j.jaci.2010.07.028. View