From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 Sep 28

PMID 39334846

Authors

Alberto Barchi

Francesco Vito Mandarino

Mona-Rita Yacoub

Luca Albarello

Luca Massimino

Edoardo Vincenzo Savarino

Federica Ungaro

Sandro Passaretti

Gwen M C Masclee

Silvio Danese

Albert J Bredenoord

Edoardo Vespa

Affiliations

Soon will be listed here.

Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. EoE shares a common pathogenetic mechanism with other chronic disorders pertaining to the type 2 inflammatory spectrum, such as atopic dermatitis (AD), allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps (CRSwNP). The recent advancements in EoE pathogenesis understanding have unveiled new molecular targets implied within the "atopic march" picture as well as specific to EoE. These discoveries have led to the clinical evaluation of several novel drugs (monoclonal antibodies and immune modulators), specifically aimed at the modulation of Th2 inflammation. In this comprehensive review, we have focused on the subtle mechanisms of type 2 inflammatory disorders, highlighting the similarities and differences with EoE, taking a deeper look into the evolving field of biologic therapies, already approved or under current investigation.

Citing Articles

New insights in the natural course of eosinophilic esophagitis.

Masclee G, Bredenoord A United European Gastroenterol J. 2024; 12(10):1348-1349.

PMID: 39508516 PMC: 11652332. DOI: 10.1002/ueg2.12702.

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