Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells Via MAPK Signaling Pathways

Overview

Journal J Oncol

Specialty Oncology

Date 2021 Nov 26

PMID 34824582

Citations 4

Authors

Sicong Jiang

Yinda Qiu

Zhaozhen Wang

Yulong Ji

Xiaofang Zhang

Xiaosong Yan

Zhiqiang Zhan

Affiliations

Soon will be listed here.

Abstract

Background: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested.

Methods: The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay.

Results: CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways.

Conclusion: Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.

Citing Articles

Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives.

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Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol.

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Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action.

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