Efficacy of Shear Wave Elasticity for Evaluating Myocardial Hypertrophy in Hypertensive Rats

Overview

Journal Sci Rep

Specialty Science

Date 2021 Nov 25

PMID 34819579

Citations 3

Authors

Yoichi Takaya

Kazufumi Nakamura

Rie Nakayama

Hiroaki Ohtsuka

Naofumi Amioka

Megumi Kondo

Kaoru Akazawa

Yuko Ohno

Keishi Ichikawa

Yukihiro Saito

Satoshi Akagi

Masashi Yoshida

Toru Miyoshi

Hiroshi Ito

Affiliations

Soon will be listed here.

Abstract

Shear wave (SW) imaging is a novel ultrasound-based technique for assessing tissue characteristics. SW elasticity may be useful to assess the severity of hypertensive left ventricular (LV) hypertrophy. This study aimed to evaluate the efficacy of SW elasticity for assessing the degree of myocardial hypertrophy using hypertensive rats. Rats were divided into hypertension group and control group. SW elasticity was measured on the excised heart. Myocardial hypertrophy was assessed histologically. LV weight was greater in hypertension group. An increase in interventricular septum and LV free wall thicknesses was observed in hypertension group. SW elasticity was significantly higher in hypertension group than in control group (14.6 ± 4.3 kPa vs. 6.5 ± 1.1 kPa, P < 0.01). The cross-sectional area of cardiomyocytes was larger in hypertension group than in control group (397 ± 50 μm vs. 243 ± 14 μm, P < 0.01), and SW elasticity was positively correlated with the cross-sectional area of cardiomyocytes (R = 0.96, P < 0.01). This study showed that SW elasticity was higher in hypertensive rats and was closely correlated with the degree of myocardial hypertrophy, suggesting the efficacy of SW elasticity for estimating the severity of hypertensive LV hypertrophy.

Citing Articles

Non-invasive Measurement of the Viscoelasticity of the Optic Nerve and Sclera for Assessing Papilledema: A Pilot Clinical Study.

Bui N, Kazemi A, Sit A, Larson N, Greenleaf J, Chen J Ultrasound Med Biol. 2023; 49(10):2227-2233.

PMID: 37517885 PMC: 10529623. DOI: 10.1016/j.ultrasmedbio.2023.07.006.

Biomedical Imaging in Experimental Models of Cardiovascular Disease.

Sosnovik D, Scherrer-Crosbie M Circ Res. 2022; 130(12):1851-1868.

PMID: 35679370 PMC: 9202007. DOI: 10.1161/CIRCRESAHA.122.320306.

Impact of shear wave dispersion slope analysis for assessing the severity of myocarditis.

Amioka N, Takaya Y, Nakamura K, Kondo M, Akazawa K, Ohno Y Sci Rep. 2022; 12(1):8776.

PMID: 35610503 PMC: 9130270. DOI: 10.1038/s41598-022-12935-6.

References

Cvijic M, Bezy S, Petrescu A, Santos P, Orlowska M, Chakraborty B . Interplay of cardiac remodelling and myocardial stiffness in hypertensive heart disease: a shear wave imaging study using high-frame rate echocardiography. Eur Heart J Cardiovasc Imaging. 2019; 21(6):664-672. DOI: 10.1093/ehjci/jez205. View

Liu Z, Jing H, Han X, Shao H, Sun Y, Wang Q . Shear wave elastography combined with the thyroid imaging reporting and data system for malignancy risk stratification in thyroid nodules. Oncotarget. 2017; 8(26):43406-43416. PMC: 5522156. DOI: 10.18632/oncotarget.15018. View

Chen S, Sanchez W, Callstrom M, Gorman B, Lewis J, Sanderson S . Assessment of liver viscoelasticity by using shear waves induced by ultrasound radiation force. Radiology. 2012; 266(3):964-70. PMC: 3579173. DOI: 10.1148/radiol.12120837. View

Nightingale K . Acoustic Radiation Force Impulse (ARFI) Imaging: a Review. Curr Med Imaging Rev. 2012; 7(4):328-339. PMC: 3337770. DOI: 10.2174/157340511798038657. View

Yamamoto K, Masuyama T, Sakata Y, Nishikawa N, Mano T, Yoshida J . Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. Cardiovasc Res. 2002; 55(1):76-82. DOI: 10.1016/s0008-6363(02)00341-3. View

Ogura I, Nakahara K, Sasaki Y, Sue M, Oda T . Usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases. Imaging Sci Dent. 2018; 48(3):161-165. PMC: 6148035. DOI: 10.5624/isd.2018.48.3.161. View

Petrescu A, Santos P, Orlowska M, Pedrosa J, Bezy S, Chakraborty B . Velocities of Naturally Occurring Myocardial Shear Waves Increase With Age and in Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2019; 12(12):2389-2398. DOI: 10.1016/j.jcmg.2018.11.029. View

Tada T, Kumada T, Toyoda H, Ito T, Sone Y, Okuda S . Utility of real-time shear wave elastography for assessing liver fibrosis in patients with chronic hepatitis C infection without cirrhosis: Comparison of liver fibrosis indices. Hepatol Res. 2015; 45(10):E122-9. DOI: 10.1111/hepr.12476. View

Takemoto M, Egashira K, Tomita H, Usui M, Okamoto H, Kitabatake A . Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis. Hypertension. 1997; 30(6):1621-7. DOI: 10.1161/01.hyp.30.6.1621. View

10.

Pislaru C, Ionescu F, Alashry M, Petrescu I, Pellikka P, Grogan M . Myocardial Stiffness by Intrinsic Cardiac Elastography in Patients with Amyloidosis: Comparison with Chamber Stiffness and Global Longitudinal Strain. J Am Soc Echocardiogr. 2019; 32(8):958-968.e4. DOI: 10.1016/j.echo.2019.04.418. View

11.

Parker K, Partin A, Rubens D . What do we know about shear wave dispersion in normal and steatotic livers?. Ultrasound Med Biol. 2015; 41(5):1481-7. DOI: 10.1016/j.ultrasmedbio.2015.01.002. View

12.

Pernot M, Couade M, Mateo P, Crozatier B, Fischmeister R, Tanter M . Real-time assessment of myocardial contractility using shear wave imaging. J Am Coll Cardiol. 2011; 58(1):65-72. DOI: 10.1016/j.jacc.2011.02.042. View

13.

Villemain O, Correia M, Khraiche D, Podetti I, Meot M, Legendre A . Myocardial Stiffness Assessment Using Shear Wave Imaging in Pediatric Hypertrophic Cardiomyopathy. JACC Cardiovasc Imaging. 2017; 11(5):779-781. DOI: 10.1016/j.jcmg.2017.08.018. View

14.

Sarvazyan A, Rudenko O, Swanson S, Fowlkes J, Emelianov S . Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. Ultrasound Med Biol. 1999; 24(9):1419-35. DOI: 10.1016/s0301-5629(98)00110-0. View

15.

Honjo M, Moriyasu F, Sugimoto K, Oshiro H, Sakamaki K, Kasuya K . Relationship between the liver tissue shear modulus and histopathologic findings analyzed by intraoperative shear wave elastography and digital microscopically assisted morphometry in patients with hepatocellular carcinoma. J Ultrasound Med. 2013; 33(1):61-71. DOI: 10.7863/ultra.33.1.61. View

16.

Pernot M, Lee W, Bel A, Mateo P, Couade M, Tanter M . Shear Wave Imaging of Passive Diastolic Myocardial Stiffness: Stunned Versus Infarcted Myocardium. JACC Cardiovasc Imaging. 2016; 9(9):1023-1030. PMC: 5019097. DOI: 10.1016/j.jcmg.2016.01.022. View

17.

Haider A, Larson M, Benjamin E, Levy D . Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol. 1998; 32(5):1454-9. DOI: 10.1016/s0735-1097(98)00407-0. View

18.

Gallego B, Arevalo M, Flores O, Lopez-Novoa J, Perez-Barriocanal F . Renal fibrosis in diabetic and aortic-constricted hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2001; 280(6):R1823-9. DOI: 10.1152/ajpregu.2001.280.6.R1823. View

19.

Muller M, Gennisson J, Deffieux T, Tanter M, Fink M . Quantitative viscoelasticity mapping of human liver using supersonic shear imaging: preliminary in vivo feasibility study. Ultrasound Med Biol. 2008; 35(2):219-29. DOI: 10.1016/j.ultrasmedbio.2008.08.018. View

20.

Evans A, Whelehan P, Thomson K, McLean D, Brauer K, Purdie C . Invasive breast cancer: relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology. 2012; 263(3):673-7. DOI: 10.1148/radiol.12111317. View