C-ferroptosis is an Iron-dependent Form of Regulated Cell Death in Cyanobacteria

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2021 Nov 24

PMID 34817556

Citations 15

Authors

Anabella Aguilera

Federico Berdun

Carlos Bartoli

Charlotte Steelheart

Matias Alegre

Hulya Bayir

Yulia Y Tyurina

Valerian E Kagan

Graciela Salerno

Gabriela Pagnussat

Maria Victoria Martin

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis sp. PCC 6803 cells undergo a cell death pathway that can be suppressed by the canonical ferroptosis inhibitors, CPX, vitamin E, Fer-1, liproxstatin-1, glutathione (GSH), or ascorbic acid (AsA). Moreover, as described for eukaryotic ferroptosis, this pathway is characterized by an early depletion of the antioxidants GSH and AsA, and by lipid peroxidation. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.

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