Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2021 Nov 23

PMID 34810213

Citations 3

Authors

Kaisa L Hanley

Yan Liang

Gaowei Wang

Xiaoxue Lin

Meixiang Yang

Michael Karin

Wenxian Fu

Gen-Sheng Feng

Affiliations

Soon will be listed here.

Abstract

Implications: We demonstrate here that basal levels of the Ras/MAPK and NF-κB pathways, while promoting tumorigenesis if overactivated, are required to maintain physiologic homeostasis and regulate circadian rhythm in the liver, which are antitumorigenic.

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