PiRNA-63049 Inhibits Bone Formation Through Wnt/β-catenin Signaling Pathway

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2021 Nov 22

PMID 34803507

Citations 11

Authors

Gaoyang Chen

Shang Wang

Canling Long

Zhenmin Wang

Xin Chen

Wanze Tang

Xiaoqin He

Zhiteng Bao

Baoyu Tan

William W Lu

Zhizhong Li

Dazhi Yang

Guozhi Xiao

Songlin Peng

Affiliations

Soon will be listed here.

Abstract

Bone remodeling is a dynamic process between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts. Disrupted bone remodeling is a key factor in postmenopausal osteoporosis, a metabolic disorder characterized by deteriorated bone microarchitecture and increased risk of fracture. Recent studies have shown that piwi-binding RNA (piRNA) is involved in the pathogenesis of certain diseases at the post-transcriptional level. Here, we analyzed piRNA-63049 (piR-63049), which may play an essential role in bone remodeling. The expression of piR-63049 significantly increased in both bone tissues and plasma of osteoporotic rats and postmenopausal osteoporotic patients. Overexpressing piR-63049 could inhibit the osteoblastogenesis of bone marrow stromal cells (BMSCs) while knocking down piR-63049 could promote the osteoblastogenesis of BMSCs through the Wnt2b/β-catenin signaling pathway. Moreover, knocking-down piR-63049 (piR-63049-antagonist) could attenuate the bone loss in ovariectomized rats by promoting bone formation. Taken together, the current study shows that piR-63049 inhibits bone formation through Wnt2b/β-catenin signaling pathway. This novel piRNA may be a potential target to increase bone formation in bone loss disorders such as postmenopausal osteoporosis.

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