The Evaluation of Healing Effect of Triclosan and Flurbiprofen-loaded Nanogels in Experimental Periodontitis in Rats by Morphometric Analysis

Overview

Journal Saudi Dent J

Specialty Dentistry

Date 2021 Nov 22

PMID 34803300

Citations 3

Authors

Nafiu Aminu

Mun-Fei Yam

Siok-Yee Chan

Idris Bello

Nura Muhammad Umar

Tanko Nuhu

Seok-Ming Toh

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis in rats.

Methodology: A total of 72 rats were used in this study. Four groups (n = 18 each) were randomly created: Group 1 - neither subjected to experimental periodontitis nor to any treatment; Group 2 - subjected to experimental periodontitis but not treated; Group 3 - subjected to experimental periodontitis and then treated with the developed nanogels; Group 4 - subjected to experimental periodontitis and then placed on a mixture of pure TCS and FLB treatment. The experimental periodontitis was induced on the lower incisors by applying a ligature which was kept for 14 days. Treatment was done for 7 days, and sampling was done at 7, 14, and 28 day of the post-induction experimental period. Morphometric analysis was conducted to assess the clinical outcomes and healing effect.

Results: The morphometric findings showed that the group treated with the developed TCS and FLB-loaded nanogels recovered better and faster than a mixture of pure TCS and FLB. At 28 day of the experimental period, there was no significant difference ( > 0.05) between the baseline control group and the nanogels treated group.

Conclusions: The developed TCS and FLB-loaded nanogels was found to be effective in the treatment of experimental periodontitis in rats. The used experimental periodontitis model was found to be simple and easily reproducible.

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