Periodontitis-activated Monocytes/macrophages Cause Aortic Inflammation

Overview

Journal Sci Rep

Specialty Science

Date 2014 Jun 5

PMID 24893991

Citations 34

Authors

Shin-Ichi Miyajima

Keiko Naruse

Yasuko Kobayashi

Nobuhisa Nakamura

Toru Nishikawa

Kei Adachi

Yuki Suzuki

Takeshi Kikuchi

Akio Mitani

Makoto Mizutani

Norikazu Ohno

Toshihide Noguchi

Tatsuaki Matsubara

Affiliations

Soon will be listed here.

Abstract

A relationship between periodontal disease and atherosclerosis has been suggested by epidemiological studies. Ligature-induced experimental periodontitis is an adequate model for clinical periodontitis, which starts from plaque accumulation, followed by inflammation in the periodontal tissue. Here we have demonstrated using a ligature-induced periodontitis model that periodontitis activates monocytes/macrophages, which subsequently circulate in the blood and adhere to vascular endothelial cells without altering the serum TNF-α concentration. Adherent monocytes/macrophages induced NF-κB activation and VCAM-1 expression in the endothelium and increased the expression of the TNF-α signaling cascade in the aorta. Peripheral blood-derived mononuclear cells from rats with experimental periodontitis showed enhanced adhesion and increased NF-κB/VCAM-1 in cultured vascular endothelial cells. Our results suggest that periodontitis triggers the initial pathogenesis of atherosclerosis, inflammation of the vasculature, through activating monocytes/macrophages.

Citing Articles

Crosstalk between periodontitis and cardiovascular risk.

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Impacts of Hyperglycemia on Epigenetic Modifications in Human Gingival Fibroblasts and Gingiva in Diabetic Rats.

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