Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma

Overview

Journal Am J Ophthalmol

Specialty Ophthalmology

Date 2021 Nov 21

PMID 34801510

Citations 7

Authors

Alireza Kamalipour

Sasan Moghimi

Huiyuan Hou

James A Proudfoot

Takashi Nishida

Linda M Zangwill

Robert N Weinreb

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the association of macular superficial vessel density (SVD) and projection-resolved deep vessel density (DVD) with past visual field (VF) progression in patients with primary open-angle glaucoma.

Design: Retrospective cohort.

Methods: In this longitudinal study, 208 eyes of 147 patients with glaucoma from the Diagnostics Innovations in Glaucoma Study were included. Eligible participants were required to have at least five 24-2 VF tests over a minimum follow-up period of 3 years before macular optical coherence tomography angiography imaging. VF progression was defined based on both event-based pointwise linear regression and trend-based methods. The association of macular SVD and DVD with the probability and rate of past VF progression was evaluated using a linear mixed effects model.

Results: Fifty-two (25%) eyes had VF progression based on the pointwise linear regression based criterion at the end of a mean ± standard deviation follow-up duration of 6.9 ± 1.2 years. In the event-based multivariable analysis, a lower baseline SVD was associated with a higher likelihood of past VF progression (odds ratio per 1% lower. 1.28; 95% confidence interval, 1.02-1.59). Similarly, in the trend-based multivariable analysis, lower macular SVD was associated with a faster past rate of mean deviation decline (coefficient = -0.03 dB/year; 95% confidence interval, -0.04 to -0.01). Event-based and trend-based analyses found no significant associations for macular DVD with the likelihood/rate of past VF progression (P > .05).

Conclusions: Lower macular SVD, and not DVD, was associated with a higher probability of past VF progression. Macular optical coherence tomography angiography imaging shows promise for identifying eyes at risk of VF progression in patients with glaucoma.

Citing Articles

Foveal avascular zone vessel density is associated with visual field progression in early-stage glaucoma eyes with central visual field damage.

Yoon J, Kim K, Lee A, Song W, Kook M Sci Rep. 2023; 13(1):18285.

PMID: 37880406 PMC: 10600159. DOI: 10.1038/s41598-023-45541-1.

Association of superficial macular vessel density with visual field progression in open-angle glaucoma with central visual field damage.

Yoon J, Lee A, Song W, Kim K, Kook M Sci Rep. 2023; 13(1):7190.

PMID: 37137927 PMC: 10156675. DOI: 10.1038/s41598-023-34000-6.

Intraocular pressure increases the rate of macular vessel density loss in glaucoma.

Mahmoudinezhad G, Moghimi S, Nishida T, Micheletti E, Du K, Mohammadzadeh V Br J Ophthalmol. 2022; 108(2):181-187.

PMID: 36535749 PMC: 10277316. DOI: 10.1136/bjo-2022-322261.

Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.

Kamalipour A, Moghimi S, Khosravi P, Mohammadzadeh V, Nishida T, Micheletti E Am J Ophthalmol. 2022; 246:141-154.

PMID: 36328200 PMC: 11789620. DOI: 10.1016/j.ajo.2022.10.016.

Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma.

Wu J, Moghimi S, Nishida T, Mahmoudinezhad G, Zangwill L, Weinreb R Br J Ophthalmol. 2022; 107(12):1828-1833.

PMID: 36150750 PMC: 10033463. DOI: 10.1136/bjo-2022-321870.

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