IL-17 and IL-17C Signaling Protects the Intestinal Epithelium Against Diisopropyl Fluorophosphate Exposure in an Acute Model of Gulf War Veterans' Illnesses

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2021 Nov 19

PMID 34796039

Citations 1

Authors

Kristen M Patterson

Tyler G Vajdic

Gustavo J Martinez

Axel G Feller

Joseph M Reynolds

Affiliations

Soon will be listed here.

Abstract

Gulf War Veterans' Illnesses (GWI) encompasses a broad range of unexplained symptomology specific to Veterans of the Persian Gulf War. Gastrointestinal (GI) distress is prominent in veterans with GWI and often presents as irritable bowel syndrome (IBS). Neurotoxins, including organophosphorus pesticides and sarin gas, are believed to have contributed to the development of GWI, at least in a subset of Veterans. However, the effects of such agents have not been extensively studied for their potential impact to GI disorders and immunological stability. Here we utilized an established murine model of GWI to investigate deleterious effects of diisopropyl fluorophosphate (DFP) exposure on the mucosal epithelium and . , acute DFP exposure negatively impacts the mucosal epithelium by reducing tight junction proteins and antimicrobial peptides as well as altering intestinal microbiome composition. Furthermore, DFP treatment reduced the expression of IL-17 in the colonic epithelium. Conversely, both IL-17 and IL-17C treatment could combat the negative effects of DFP and other cholinesterase inhibitors in murine intestinal organoid cells. Our findings demonstrate that acute exposure to DFP can result in rapid deterioration of mechanisms protecting the GI tract from disease. These results are relevant to suspected GWI exposures and could help explain the propensity for GI disorders in GWI Veterans.

Citing Articles

Chemical exposures and suspected impact on Gulf War Veterans.

Elhaj R, Reynolds J Mil Med Res. 2023; 10(1):11.

PMID: 36882803 PMC: 9993698. DOI: 10.1186/s40779-023-00449-9.

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