Mechanisms of Myocardial Edema Development in CVD Pathophysiology

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 Feb 24

PMID 38398066

Authors

Diana G Kiseleva

Tatiana V Kirichenko

Yuliya V Markina

Vadim R Cherednichenko

Ekaterina A Gugueva

Alexander M Markin

Affiliations

Soon will be listed here.

Abstract

Myocardial edema is the excess accumulation of fluid in the myocardial interstitium or cardiac cells that develops due to changes in capillary permeability, loss of glycocalyx charge, imbalance in lymphatic drainage, or a combination of these factors. Today it is believed that this condition is not only a complication of cardiovascular diseases, but in itself causes aggravation of the disease and increases the risks of adverse outcomes. The study of molecular, genetic, and mechanical changes in the myocardium during edema may contribute to the development of new approaches to the diagnosis and treatment of this condition. This review was conducted to describe the main mechanisms of myocardial edema development at the molecular and cellular levels and to identify promising targets for the regulation of this condition based on articles cited in Pubmed up to January 2024.

Citing Articles

Arrhythmogenic Potential of Myocardial Edema: The Interstitial Osmolality Induces Spiral Waves and Multiple Excitation Wavelets.

Kiseleva D, Dzhabrailov V, Aitova A, Turchaninova E, Tsvelaya V, Kazakova M Biomedicines. 2024; 12(8).

PMID: 39200234 PMC: 11351629. DOI: 10.3390/biomedicines12081770.

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