Role of the Prefrontal Cortex in Prosocial and Self-maximization Motivations: an RTMS Study

Overview

Journal Sci Rep

Specialty Science

Date 2021 Nov 17

PMID 34785670

Citations 4

Authors

Oksana Zinchenko

Olga Savelo

Vasily Klucharev

Affiliations

Soon will be listed here.

Abstract

More than a decade of neuroimaging and brain stimulation studies point to a crucial role for the right dorsolateral prefrontal cortex (rDLPFC) in prosocial behavior. The intuitive prosociality model postulates that the rDLPFC controls intuitive prosocial behavior, whereas the reflective model assumes that the rDLPFC controls selfish impulses during prosocial behavior. The intuitive prosociality model implies that the transient disruption of the rDLPFC should increase voluntary transfers in both dictator and generosity games. In contrast, the reflective model suggests that the transient disruption of the rDLPFC should decrease transfers in the dictator game, without affecting voluntary transfers in the generosity game, in which selfish motives are minimized. The aim of this paper was to compare predictions of the intuitive and reflective models using the classic dictator game and generosity game and continuous theta burst stimulation (cTBS). In this study, two groups of healthy participants (dictators) received either cTBS over the rDLPFC or right extrastriate visual areas. As shown by the results, the transient disruption of the rDLPFC significantly promoted prosocial motives in the dictator game only, particularly in the trials with the lowest dictator's costs. These findings partially support the notion that the rDLPFC controls intuitive prosocial behavior.

Citing Articles

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References

Knoch D, Pascual-Leone A, Meyer K, Treyer V, Fehr E . Diminishing reciprocal fairness by disrupting the right prefrontal cortex. Science. 2006; 314(5800):829-32. DOI: 10.1126/science.1129156. View

Knoch D, Fehr E . Resisting the power of temptations: the right prefrontal cortex and self-control. Ann N Y Acad Sci. 2007; 1104:123-34. DOI: 10.1196/annals.1390.004. View

Knoch D, Schneider F, Schunk D, Hohmann M, Fehr E . Disrupting the prefrontal cortex diminishes the human ability to build a good reputation. Proc Natl Acad Sci U S A. 2009; 106(49):20895-9. PMC: 2785725. DOI: 10.1073/pnas.0911619106. View

Spitzer M, Fischbacher U, Herrnberger B, Gron G, Fehr E . The neural signature of social norm compliance. Neuron. 2007; 56(1):185-96. DOI: 10.1016/j.neuron.2007.09.011. View

Ruff C, Ugazio G, Fehr E . Changing social norm compliance with noninvasive brain stimulation. Science. 2013; 342(6157):482-4. DOI: 10.1126/science.1241399. View

Christov-Moore L, Sugiyama T, Grigaityte K, Iacoboni M . Increasing generosity by disrupting prefrontal cortex. Soc Neurosci. 2016; 12(2):174-181. PMC: 5593255. DOI: 10.1080/17470919.2016.1154105. View

Yamagishi T, Takagishi H, Fermin A, Kanai R, Li Y, Matsumoto Y . Cortical thickness of the dorsolateral prefrontal cortex predicts strategic choices in economic games. Proc Natl Acad Sci U S A. 2016; 113(20):5582-7. PMC: 4878491. DOI: 10.1073/pnas.1523940113. View

de Waal F . Putting the altruism back into altruism: the evolution of empathy. Annu Rev Psychol. 2007; 59:279-300. DOI: 10.1146/annurev.psych.59.103006.093625. View

Zaki J, Ochsner K, Ochsner K . The neuroscience of empathy: progress, pitfalls and promise. Nat Neurosci. 2012; 15(5):675-80. DOI: 10.1038/nn.3085. View

10.

Knoch D, Nitsche M, Fischbacher U, Eisenegger C, Pascual-Leone A, Fehr E . Studying the neurobiology of social interaction with transcranial direct current stimulation--the example of punishing unfairness. Cereb Cortex. 2007; 18(9):1987-90. DOI: 10.1093/cercor/bhm237. View

11.

Baumgartner T, Knoch D, Hotz P, Eisenegger C, Fehr E . Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice. Nat Neurosci. 2011; 14(11):1468-74. DOI: 10.1038/nn.2933. View

12.

Tabibnia G, Satpute A, Lieberman M . The sunny side of fairness: preference for fairness activates reward circuitry (and disregarding unfairness activates self-control circuitry). Psychol Sci. 2008; 19(4):339-47. DOI: 10.1111/j.1467-9280.2008.02091.x. View

13.

Steinbeis N, Bernhardt B, Singer T . Impulse control and underlying functions of the left DLPFC mediate age-related and age-independent individual differences in strategic social behavior. Neuron. 2012; 73(5):1040-51. DOI: 10.1016/j.neuron.2011.12.027. View

14.

Stevens J, Hauser M . Why be nice? Psychological constraints on the evolution of cooperation. Trends Cogn Sci. 2004; 8(2):60-5. DOI: 10.1016/j.tics.2003.12.003. View

15.

Zhao K, Ferguson E, Smillie L . Prosocial Personality Traits Differentially Predict Egalitarianism, Generosity, and Reciprocity in Economic Games. Front Psychol. 2016; 7:1137. PMC: 4977318. DOI: 10.3389/fpsyg.2016.01137. View

16.

Brune M, Juckel G, Enzi B . "An eye for an eye"? Neural correlates of retribution and forgiveness. PLoS One. 2013; 8(8):e73519. PMC: 3756996. DOI: 10.1371/journal.pone.0073519. View

17.

Rangel A, Hare T . Neural computations associated with goal-directed choice. Curr Opin Neurobiol. 2010; 20(2):262-70. DOI: 10.1016/j.conb.2010.03.001. View

18.

Padoa-Schioppa C . Neurobiology of economic choice: a good-based model. Annu Rev Neurosci. 2011; 34:333-59. PMC: 3273993. DOI: 10.1146/annurev-neuro-061010-113648. View

19.

Rushworth M, Noonan M, Boorman E, Walton M, Behrens T . Frontal cortex and reward-guided learning and decision-making. Neuron. 2011; 70(6):1054-69. DOI: 10.1016/j.neuron.2011.05.014. View

20.

Kable J, Glimcher P . The neural correlates of subjective value during intertemporal choice. Nat Neurosci. 2007; 10(12):1625-33. PMC: 2845395. DOI: 10.1038/nn2007. View