Prenatal Particulate Matter Exposure and Mitochondrial Mutational Load at the Maternal-fetal Interface: Effect Modification by Genetic Ancestry

Overview

Journal Mitochondrion

Specialty Cell Biology

Date 2021 Nov 17

PMID 34785263

Citations 6

Authors

Kelly J Brunst

Hsiao-Hsien Leon Hsu

Li Zhang

Xiang Zhang

Kecia N Carroll

Allan Just

Brent A Coull

Itai Kloog

Robert O Wright

Andrea A Baccarelli

Rosalind J Wright

Affiliations

Soon will be listed here.

Abstract

Prenatal ambient particulate matter (PM) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PMexposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

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