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Social Contact Reinforces Cocaine Self-Administration in Young Adult Male Rats: The Role of Social Reinforcement in Vulnerability to Drug Use

Overview
Specialty Psychology
Date 2021 Nov 15
PMID 34776897
Citations 9
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Abstract

Drug-using peers are recognized as a leading factor influencing drug use among adolescents and young adults. One mechanism by which peers influence drug use is by providing social reinforcement for using drugs. Social reinforcement may be provided in multiple ways, including by making social contact contingent on drug use (i.e., an individual must use drugs to gain/maintain access to a peer). The purpose of this study was to develop a preclinical model in which intravenous cocaine self-administration was positively reinforced by access to a social partner. Young adult male rats were trained to self-administer cocaine in operant conditioning chambers with a guillotine door that could be opened to an adjacent compartment housing either a social partner or a non-social stimulus. Once cocaine self-administration was established, the guillotine door was activated, and cocaine intake was reinforced by brief access to either a social (age- and sex-matched peer) or non-social (black-and-white athletic sock) stimulus. Contingent access to a social partner rapidly increased cocaine self-administration. Total cocaine intake was 2- to 3-fold greater in rats assigned to the social versus non-social condition across a 100-fold dose range. Cocaine intake rapidly increased when rats in the original non-social group were later provided with social partners, whereas cocaine intake resisted change and remained elevated when rats in the original social group had their partners removed. These data indicate that contingent access to a social partner increases drug intake and suggest that social reinforcement may represent a vulnerability factor that is particularly resistant to psychosocial interventions.

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References
1.
McMillan C, Felmlee D, Osgood D . Peer Influence, Friend Selection, and Gender: How Network Processes Shape Adolescent Smoking, Drinking, And Delinquency. Soc Networks. 2019; 55:86-96. PMC: 6433147. DOI: 10.1016/j.socnet.2018.05.008. View

2.
Venniro M, Panlilio L, Epstein D, Shaham Y . The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward. Neuropsychopharmacology. 2021; 46(13):2350-2357. PMC: 8580997. DOI: 10.1038/s41386-021-01148-6. View

3.
Barnett N, Ott M, Rogers M, Loxley M, Linkletter C, Clark M . Peer associations for substance use and exercise in a college student social network. Health Psychol. 2013; 33(10):1134-42. DOI: 10.1037/a0034687. View

4.
Fritz M, El Rawas R, Salti A, Klement S, Bardo M, Kemmler G . Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats. Addict Biol. 2011; 16(2):273-84. DOI: 10.1111/j.1369-1600.2010.00285.x. View

5.
Venniro M, Zhang M, Shaham Y, Caprioli D . Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats. Neuropsychopharmacology. 2016; 42(5):1126-1135. PMC: 5506794. DOI: 10.1038/npp.2016.287. View