» Articles » PMID: 34761489

Aggregation-Enhanced Sonodynamic Activity of Phthalocyanine-Artesunate Conjugates

Overview
Specialty Chemistry
Date 2021 Nov 11
PMID 34761489
Citations 14
Authors
Affiliations
Soon will be listed here.
Abstract

The clinical prospect of sonodynamic therapy (SDT) has not been fully realized due to the scarcity of efficient sonosensitizers. Herein, we designed phthalocyanine-artesunate conjugates (e.g. ZnPcT A), which could generate up to ca. 10-fold more reactive oxygen species (ROS) than the known sonosensitizer protoporphyrin IX. Meanwhile, an interesting and significant finding of aggregation-enhanced sonodynamic activity (AESA) was observed for the first time. ZnPcT A showed about 60-fold higher sonodynamic ROS generation in the aggregated form than in the disaggregated form in aqueous solutions. That could be attributed to the boosted ultrasonic cavitation of nanostructures. The level of the AESA effect depended on the aggregation ability of sonosensitizer molecules and the particle size of their aggregates. Moreover, biological studies demonstrated that ZnPcT A had high anticancer activities and biosafety. This study thus opens up a new avenue the development of efficient organic sonosensitizers.

Citing Articles

Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment.

Yang M, Wang X, Peng M, Wang F, Hou S, Xing R Nanomicro Lett. 2025; 17(1):157.

PMID: 39992547 PMC: 11850698. DOI: 10.1007/s40820-025-01666-8.


Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy.

Chen J, Zhan Q, Li L, Xi S, Cai L, Liu R Mater Today Bio. 2025; 30():101407.

PMID: 39811609 PMC: 11732120. DOI: 10.1016/j.mtbio.2024.101407.


Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections.

Ge M, Jiang F, Lin H Mater Today Bio. 2024; 29:101255.

PMID: 39381264 PMC: 11459013. DOI: 10.1016/j.mtbio.2024.101255.


NIR laser-activated phthalocyanine loaded lipid nanoparticles targeting M2 macrophage for improved photoacoustic imaging-guided photothermal therapy.

Peng X, Wang J, Deng Z, Wei J, Xie C, Wang Y Mater Today Bio. 2024; 28:101209.

PMID: 39221205 PMC: 11364919. DOI: 10.1016/j.mtbio.2024.101209.


Exosome-drug conjugates delivery: a promising strategy for ameliorating the pharmacokinetic profile of artesunate.

Wang D, Bai Y, Cheng G, Shen S, Xiao G, Ma D Front Bioeng Biotechnol. 2024; 12:1437787.

PMID: 39188369 PMC: 11345266. DOI: 10.3389/fbioe.2024.1437787.